Referencias científicas

Grupos de riesgo

Aire

Alimentos

 Higiene personal

Productos de limpieza

Construcción y decoración

Agua

Otras fuentes de exposición

Enfermedades causadas por tóxicos

Sustancias y agentes tóxicos

PROBLEMAS EN LOS NIÑOS

The relationship between housing and health: children at risk. Breysse P, Farr N, Galke W, Lanphear B, Morely R, Bergofsky L. Environ Health Perspect. 2004;112:1583–1588.

Total health assessment of chemicals in indoor climate from various consumer products. Survey of Chemical Substances in Consumer Products, No. 75 2006. Environmental Protection Agency. Danish Ministry of the Environment.

La exposición humana y los peligros para la salud. Parte 2. Steinemann A. (2005) Edición Electrónica en Castellano de Rachel´s Environment & Health News 811. Salud y Medio Ambiente. Boletín Informativo 811. Peter Montague Editor.

Frequent use of chemical household products is associated with persistent wheezing in pre-school age children. A Sherriff, A Farrow, J Golding, the ALSPAC Study Team, J Henderson. Thorax 2005;60:45–49.

Association of domestic exposure to volatile organic compounds with asthma in young children. K Rumchev1, J Spickett1, M Bulsara2, M Phillips1, S Stick3. Thorax 2004;59:746-751 doi:10.1136/thx.2003.013680

Atshma symptoms in hispanic children and daily ambient exposures to toxic and criteria air pollutants.  Delfino RJ et al. (2003). Environmental Health Perspectives 111 (4): 647-656

The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Bornehag, CG. et al. Environ Health Perspect 2004; 112(14):1393-1397.

Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides. Pediatrics Vol. 125 No. 6 June 2010, pp. e1270-e1277

Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuatorian school children. Grandjean P, Harari R, Barr DB, Debes F. Pediatrics. 2006;117(3).

Long-term neurobehavioral health effects of methyl parathion exposure in children in Mississippi and Ohio. Ruckart PZ, Kakolewski K, Bove FJ, Kaye WE. Environ Health Perspect. 2004;112(1):46–51 

Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. Rohlman DS, Arcury TA, Quandt SA, et al. Neurotoxicology. 2005;26(4):589–598.

Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the US population. Barr DB, Bravo R, Weerasekera G, et al. Environ Health Perspect. 2004;112(2):186–200

Vulnerability of children and the developing brain to neurotoxic hazards. Weiss B. Environ Health Perspect. 2000;108(suppl 3):375–381

Pediatric Acute Lymphoblastic Leukemia and Exposure to Pesticides. Soldin O et al. Therapeutics drug monitoring. August 2009. Vol. 31 (4) : 495-501

Residential Pesticides and Childhood Leukemia: A Systematic Review 
and Meta-Analysis. Turner MC, Wigle DT, Krewski D 2010. Environ Health Perspect 118:33-41.

Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes. Searles Nielsen S, McKean-Cowdin R, Farin FM, Holly EA, Preston-Martin S, Mueller BA. Environ Health Perspect. 2010 Jan;118(1):144-9.

A case-control study of childhood brain tumors and fathers' hobbies: a Children's Oncology Group study. Rosso AL, Hovinga ME, Rorke-Adams LB, Spector LG, Bunin GR; Children's Oncology Group. Cancer Causes Control. 2008 Dec;19(10):1201-7. Epub 2008 Jun 17.

Household pesticides and risk of pediatric brain tumors. Pogoda JM, Preston-Martin S. Environ Health Perspect. 1997 Nov;105(11):1214-20.

Association between prenatal pesticide exposures and the generation of leukemia-associated T(8;21). Lafiura KM, Bielawski DM, Posecion NC Jr, Ostrea EM Jr, Matherly LH, Taub JW, Ge Y. Pediatr Blood Cancer. 2007 Oct 15;49(5):624-8.

Household exposure to pesticides and risk of childhood acute leukaemia. Menegaux F, Baruchel A, Bertrand Y, Lescoeur B, Leverger G, Nelken B, Sommelet D, Hémon D, Clavel J. Occup Environ Med. 2006 Feb;63(2):131-4.

Critical windows of exposure to household pesticides and risk of childhood leukemia. Xiaomei Ma, Patricia A Buffler, Robert B Gunier, Gary Dahl, Martyn T Smith, Kyndaron Reinier, and Peggy Reynolds.  Environ Health Perspect. 2002 September; 110(9): 955–960.

Childhood leukemia and pesticides. Zahm SH. Epidemiology. 1999 Sep;10(5):473-5.

Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Infante-Rivard C, Labuda D, Krajinovic M, Sinnett D. Epidemiology. 1999 Sep;10(5):481-7.

Residential pesticide exposure and neuroblastoma. Daniels JL, Olshan AF, Teschke K, Hertz-Picciotto I, Savitz DA, Blatt J, Bondy ML, Neglia JP, Pollock BH, Cohn SL, Look AT, Seeger RC, Castleberry RP. Epidemiology: 12(1):20-26, January, 2001

Leukemia and Non-Hodgkin's Lymphoma in Childhood and Exposure to Pesticides: Results of a Register-based Case-Control Study in Germany. Rolf Meinert, Joachim Schüz, Uwe Kaletsch, Peter Kaatsch and Jōrg Michaelis. Am. J. Epidemiol. (2000) 151 (7): 639-646.

Family pesticide use and childhood brain cancer. Davis JR, Brownson RC, Garcia R, Bentz BJ, Turner A. Arch Environ Contam Toxicol. 1993 Jan;24(1):87-92.

Lee DH, Jacobs DR, Porta M (2007). Associations of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. J Epidemiol Community Health. 61: 591-596.

Intellectual Impairment in Children with blood lead concentrations below 10 microg per deciliter. Canfield R.L., et al. NEJM 2003; 348(16):1517-1526.

Chronic Effects of Toxic Environmental Exposures on Children's Health. Landigran P.J. and Garg A. Clin Toxicol 2002;40(4):449-456.

Children's health and the environment: public health issues and challenges for risk assessment. Philip J Landrigan, Carole A Kimmel, Adolfo Correa, and Brenda Eskenazi. Environ Health Perspect. 2004 February; 112(2): 257–265.

Environmental Pediatrics and Its Impact on Government Health Policy. Lynn Goldman, Henry Falk, Philip J. Landrigan, Sophie J. Balk,J. Routt Reigart,  Ruth A. Etzel,  Pediatrics. Vol. 113 No. Supplement 3 April 1, 2004 pp. 1146 -1157

Exposures to environmental toxicants and attention deficit hyperactivity disorder in US children. Braun JM et al. (2006). Environ Heath Perspect 114: 1904-1909

Bone lead levels in adjudicated delinquents: a case control study. Needleman et al.(2002). Neurotoxicol Teratol 24: 711-717

Bone lead levels and delinquent behavior. Needleman HL et al. (1996). JAMA 275: 363-369

Wright JP et al. Association of  prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. Public Library of Science. Medicine. May 2008. Vol 5. Issue 5. 732-740

Developmental Exposure to Low Dose PBDE-99: Effects on Male Fertility and Neurobehavior in Rat Offspring. Kuriyama, SN. et al. Environ Health Perspect 2005;113(2):149-154.

Developmental disabilities impairment of childrens brain development and function: the role of environmental factors. Schettler, T. Peer-reviewed report for Collaborative on Health and the Environment.

In Harm's Way: Toxic Threats to Child Development. Schettler, T. et al. A Report by the Greater Boston Physicians for Social Responsibility. January 2001.

Developmental Considerations of Neurotoxic Exposures. Trask C.L. and Kosofsky B.E Neurologic Clinics 2000; 18(3):541-562.

Investigations of Strain and/or Gender Differences in Developmental Neurotoxic Effects of Polybrominated Diphenyl Ethers in Mice. Viberg, H. et al. Toxicol Sci. 2004;81(2):344-353.

CHE Toxicant and Disease Database. ADD/ADHD, hyperactivity

Neurotóxicos medioambientales (I). Pesticidas: efectos adversos en el sistema nervioso fetal y posnatal. J.A. Ortega García, J. Ferrís i Tortajada, A. Canovas Conesa, E. Apolinar Valiente, E. Crehuá Gaudiza, J. García i Castell, M. Carmona Calvo. Acta Pediatr Esp. 2005; 63: 140-149


PROBLEMAS EN EL EMBARAZO

Environmental Chemicals in Pregnant Women in the US: NHANES 2003-2004. Woodruff TJ, Zota AR, Schwartz JM 2011. Environ Health Perspect :-. doi:10.1289/ehp.1002727

Effect of Environmental Agents on Pregnancy Outcomes: Disturbances of Prenatal Growth and Development. Cordero, J.F. Med Clin North Am 1990;74(2):279-290.

Impact of prenatal exposure to Piperonyl butoxide and Permethrin on 36-month neurodevelopment. Horton et al. 2011. Pediatrics

Developmental neurotoxicity of piretroid insecticides: critical review and future research needs. Shafer et al. Envir. Health Persp. 2005, 113 (2)

Impact of prenatal chlorpiriphos exposure on neurodevelopment in the first 3 years of life among inner-city children. Rauh et al. 2008. Pediatrics  118 (6).

Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Eskenazi B, Marks AR, Bradman A, et al. Environ Health Perspect. 2007;115(5):792–798.

Symptoms of mothers and infants related to total volatile organic compounds in household products. Farrow A et al. 2003. Arch Environ Health  58(10): 633-41 .

Household chemicals: good housekeeping or occupational hazard? Editorial. European Respiratory Journal 2008; 31: 489–491

Household chemicals, persistent wheezing and lung function: effect modification by atopy? Henderson J, Sherriff A, Farrow A, Ayres JG. Eur Respir J 2008; 31: 547–554.

Frequent use of chemical household products is associated with persistent wheezing in pre-school age children. Sherriff A, Farrow A, Golding J, Henderson J. 2005. Thorax. Jan;60(1):45-9.

Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. Delfino RJ. Environ Health Perspect 2002;110: Suppl. 4 573–589.

Exposure to bisphenol A is associated with recurrent miscarriage. Sugiura-Ogasawara, M., et al., Hum Reprod, 2005. 20(8): p. 2325-2329.

Preconception Serum DDT and Pregnancy Loss: A Prospective Study Using a Biomarker of Pregnancy. Venners, S., et al., Am J Epidemiol, 2005. 162(8): p. 1-8.

Household exposure to pesticides and risk of childhood hematopoietic malignancies: The ESCALE study (SFCE). Rudant J, Menegaux F, Leverger G, Baruchel A, Nelken B, Bertrand Y, Patte C, Pacquement H, Vérité C, Robert A, Michel G, Margueritte G, Gandemer V, Hémon D, Clavel J. Environ Health Perspect. 2007 Dec;115(12):1787-93.

Critical windows of exposure to household pesticides and risk of childhood leukemia. Xiaomei Ma, Patricia A Buffler, Robert B Gunier, Gary Dahl, Martyn T Smith, Kyndaron Reinier, and Peggy Reynolds.  Environ Health Perspect. 2002 September; 110(9): 955–960.

Home pesticide use and childhood cancer: a case-control study. J K Leiss and D A Savitz. Am J Public Health. 1995 February; 85(2): 249–252.

Childhood leukemia and parents' occupational and home exposures. Lowengart RA, Peters JM, Cicioni C, Buckley J, Bernstein L, Preston-Martin S, Rappaport E. J Natl Cancer Inst. 1987 Jul;79(1):39-46.

Residential Pesticides and Childhood Leukemia: A Systematic Review 
and Meta-Analysis. Turner MC, Wigle DT, Krewski D 2010. Environ Health Perspect 118:33-41.

Pesticide exposures in children with non-Hodgkin lymphoma. Buckley JD, Meadows AT, Kadin ME, Le Beau MM, Siegel S, Robison LL. Cancer. 2000 Dec 1;89(11):2315-21.

"Mujer y condiciones de trabajo: riesgos en el embarazo en peluqueras". Departamento de Medicina Preventiva y Salud Pública de la Universidad de Alicante.2007

"Gestión de la reproducción, embarazo y lactancia natural".  Secretaría de Salud Laboral. CC.OO. de Madrid. Primera edición en diciembre 2009.

Orientaciones para la valoración del riesgo laboral y la incapacidad temporal durante el embarazo. SEGO. Enero 2008

Exposure to ethylene glycol monomethyl ether: clinical and cytogenetic findings. El-Zein, RA et al. Arch Environ Health 2002; 57(4):371-6.

Pregnancy Outcome Following Gestational Exposure to Organic Solvents. Khattak, S. et al. A Prospective Controlled Study. JAMA 1999; 281:1106-1109.

Bisphenol a exposure causes meiotic aneuploidy in the female mouse. Hunt, P.A. et al. Curr Biol 2003;13(7):546-553.

CHE Toxicant and Disease Database. Congenital malformations - general

Drinking Water Contamination and Adverse Pregnancy Outcomes: A Review. Bove F., et al. Environ Health Perspect 2002;110(1):61-74.

Pregnancy Outcome Following Gestational Exposure to Organic Solvents. Khattak, S. et al. A Prospective Controlled Study. JAMA 1999; 281:1106-1109.

Systematic Review of Pesticide Human Health Effects. Ontario College of Family Physicians. Sanborn, MS. et al. April, 2004.

In Harm's Way: Toxic Threats to Child Development. Schettler, T. et al. A Report by the Greater Boston Physicians for Social Responsibility. January 2001.

CHE Toxicant and Disease Database. Cardiac congenital malformations

Association between prenatal exposure to phthalates and the health of newborns. Huang PC, Kuo PL, Chou YY, Lin SJ, Lee CC. Environ Int. 2009 Jan;35(1):14-20. Epub 2008 Jul 21.

Phthalate Exposure and Human Semen Parameters. Duty, S.M. et al. Epidemiology 2003;14:269-77.

Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Gray, L. E., Jr., Ostby, J., Furr, J., Price, M., Veeramachaneni, D. N., & Parks, L. 2000. Toxicol Sci, 58(2): 350-365.

Prenatal phthalate exposure and reduced masculine play in boys. Swan SH, Liu F, Hines M, Kruse RL, Wang C, Redmon JB, Sparks A, Weiss B. Int J Androl. 2010 Apr;33(2):259-69. Epub 2009 Nov 16.

Decrease in anogenital distance among male infants with prenatal phthalate exposure. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, et al. 2005. Environ Health Perspect 113:1056–1061.

Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Huang PC, Kuo PL, Guo YL, Liao PC, Lee CC. Hum Reprod. 2007 Oct;22(10):2715-22. Epub 2007 Aug 17.

Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Gupta, C. 2000. Proc Soc Exp Biol Med, 224(2): 61-68.

Environmental toxicants and female reproduction. Sharara, F.I., D.B. Seifer, and J.A. Flaws, Fertil Steril, 1998. 70(4): p. 613-22.

Pregnancy Outcome Following Gestational Exposure to Organic Solvents. Khattak, S. et al. A Prospective Controlled Study. JAMA 1999; 281:1106-1109.

Maternal and Paternal Risk Factors for Cyrptorchidism and Hypospadias: A Case-Control Study in Newborn Boys. Peirik, FH. et al. Environ Health Perspect 2004;112:1570-1576.

CHE Toxicant and Disease Database. Genito-urinary malformations (includes male and female)

Ambient Air Pollution: Health Hazards to Children. Amercian Academy of Pediatrics, Committee on Environmental Health. Pediatrics 2004; 114(6):1699-1707.

Drinking Water Contamination and Adverse Pregnancy Outcomes: A Review. Bove F., et al. Environ Health Perspect 2002;110(1):61-74.

Air pollution and health. Brunekeef B, Holgate S. Lancet. 2002 Oct 19;360(9341):1233-42.

Occupational Exposures to Metals, Solvents, and Pesticides: Recent Evidence on Male Reproductive Effects and Biological Markers. Figa-Talamanca I. et al. Occup Med 2001;51(3):174-188.

Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Longnecker, M.P. et al. Lancet 2001; 358:110-114.

Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Whyatt, RM. Et al. Environ Health Perspect. 2004;112(10):1125-1132.

CHE Toxicant and Disease Database. Low birth weight / small for gestational age / intra-uterine growth retardation

Drinking Water Contamination and Adverse Pregnancy Outcomes: A Review. Bove F., et al. Environ Health Perspect 2002;110(1):61-74.

ToxFAQs™ - Clorofenoles (Chlorophenols). ATSDR.

Toxicant and Disease Database. Neural tube defects / CNS malformations

CHE Toxicant and Disease Database. Skeletal malformations

Drinking Water Contamination and Adverse Pregnancy Outcomes: A Review. Bove F., et al. Environ Health Perspect 2002;110(1):61-74.

Gene/environment causes of cleft lip and/or palate.Murray JC. Clin Genet 2002;61:248-256.

CHE Toxicant and Disease Database. Oral clefts (cleft lip and palate)

In Utero Exposure to Di-(2-Ethylhexyl)-phthalate and Human Pregnancy Duration. Giuseppe, L. et al. Environ Health Perspect. 2003; on line: http://dx.doi.org DOI: 10.1289/ehp.6202. 8/18/03

Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Longnecker, M.P. et al. Lancet 2001; 358:110-114.

Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction. Wang X, et al. Am J Epidem 2000: 152(8):701-703.

CHE Toxicant and Disease Database. Preterm delivery

Urinary phthalate metabolites in relation to preterm birth in Mexico City. Meeker JD, Hu H, Cantonwine DE, Lamadrid-Figueroa H, Calafat AM, Ettinger AS, et al. 2009. Environ Health Perspect 117:1587-1592. doi:10.1289/ehp.0800522

Prenatal Di(2-ethylhexyl)Phthalate Exposure and Length of Gestation Among an Inner-City Cohort. Whyatt RM, Adibi JJ, Calafat AM, Camann DE, Rauh V, Bhat HK, Perera FP, Andrews H, Just AC, Hoepner L, Tang D, Hauser R. [Journal Article] Pediatrics 2009 Dec; 124(6):e1213-20

Decrease in anogenital distance among male infants with prenatal phthalate exposure. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, et al. 2005. Environ Health Perspect 113:1056–1061.

AIRE

What household chemicals and products can pollute indoor air?. The SCHER opinion states.

Opinion on risk assessment on indoor air quality. Scientific Committee on Health and Environmental Risks (SCHER). Approved by the SCHER at the 17th plenary of 29 May 2007 after public consultation.

Total health assessment of chemicals in indoor climate from various consumer products. Allan Astrup Jensen  FORCE Technology and Henrik N. Knudsen SBi-Danish Building Research Institute. Survey of Chemical Substances in Consumer Products, No. 75 2006. Environmental Protection Agency. Ministry of the Environment. Denmark.



COMPUESTOS ORGÁNICOS VOLÁTILES

Determinación de hidrocarburos aromáticos (benceno, tolueno, etilbenceno, p-xileno, 1,2,4-trimetilbenceno) en aire - Método de adsorción en carbón activo / Cromatografía de gases.  MTA/MA-030/A92. INSHT

Métodos de toma de muestras y análisis. INSHT.

Agencia de Protección Ambiental de los Estados Unidos, Oficina del Aire y Radiación. Report to Congress on Indoor Air quality, Volume II: Assessment and Control of Indoor Air Pollution, pp. i,4-14. EPA-400-1-89-00IC, 1989.

Agencia de Protección Ambiental de los Estados Unidos, Servicio de Salud Pública y Asociación Nacional de Salud Ambiental. Introduction to Indoor Air Quality: A Reference Manual, p. 87. EPA-400-3-91-003, 1991.

An Introduction to Indoor Air Quality (IAQ).Volatile Organic Compounds (VOCs). EPA . USA.

WHO guidelines for indoor air quality: selected pollutants. WHO Regional Office for Europe

The right to healthy indoor air. Report on a WHO meeting, Bilthoven, Netherlands, 15–17 May 2000. Copenhagen, WHO Regional Office for Europe, 2000.

Critical appraisal of the setting and implementation of indoor exposure limits in the EU. Brussels, European Commission, Joint Research Centre, 2005.

Small chamber tests for measurement of VOC emissions from flooring adhesives. Yu CWF, Crump DR. Indoor and Built Environment, 2003, 12:299–310.

Volatile organic compounds. Sources, measurements, emissions, and the impact on indoor air quality. Wolkoff, P. Indoor Air, 1995, 5(Suppl. 3):1–73.

Influence of basement, garages and common hallways on indoor residential volatile organic compound concentrations. Dodson RE et al. Atmospheric Environment, 2008, 42:1569–1581

Concentrations and sources of VOCs in urban domestic and public microenvironments. Kim YM, Harrad S, Harrison RM. Environmental Science & Technology, 2001, 35:997–1004.

Migration of volatile organic compounds from attached garages to residences: a major exposure source. Batterman S, Jia CR, Hatzivasilis G. Environmental Research, 2007, 104:224–240

Estimating volatile organic compound concentrations in selected microenvironments using time–activity and personal exposure data. Sexton K et al. Journal of Toxicology and Environmental Health, Part A, Current Issues, 2007, 70:465–476.

Indoor pollutants emitted by office equipment. A review of reported data and information needs. Destaillats H et al. Atmospheric Environment, 2008, 42:1371–1388.

VOCs in industrial, urban and suburban neighbourhoods – Part 1: Indoor and outdoor concentrations, variation and risk drivers. Jia CR, Batterman S, Godwin C. Atmospheric Environment, 2008, 42:2083–2100.

Exposure to volatile organic compounds found to be important in the cause of childhood asthma. Occup Environ Med 2004;61:923

Real Decreto 227/2006, de 24 de febrero, por el que se complementa el régimen jurídico sobre la limitación de las emisiones de compuestos orgánicos volátiles en determinadas pinturas y barnices y en productos de renovación del acabado de vehículos.

Directiva 2004/42/CE del Parlamento Europeo y del Consejo, de 21 de abril de 2004, relativa a la limitación de las emisiones de compuestos orgánicos volátiles (COV) debidas al uso de disolventes orgánicos en determinadas pinturas y barnices y en los productos de renovación del acabado de vehículos, por la que se modifica la Directiva 1999/13/CE

Real Decreto 117/2003, de 31 de enero, sobre limitación de emisiones de compuestos orgánicos volátiles debidas al uso de disolventes en determinadas actividades

Directiva 1999/13/CE del Consejo de 11 de marzo de 1999 relativa a la limitación de las emisiones de compuestos orgánicos volátiles debidas al uso de disolventes orgánicos en determinadas actividades e instalaciones

Magrama. De compuestos orgánicos volátiles.

Quality of indoor residential air and health. Dales, R; Liu, L; Wheeler, AJ; Gilbert, NL (July 2008). Canadian Medical Association Journal (Canadian Medical Association Journal) 179 (2) (2): 147–52.

Impact of reaction products from building materials and furnishings on indoor air quality – a review of recent advances in indoor chemistry. Uhde E, Salthammer T. Atmospheric Environment, 2007, 41:3111–3128

Exposure to air pollutants in English homes. Journal of Exposure Raw GJ et al. Analysis and Environmental Epidemiology, 2004, 14:S85–S94.

Residential exposure to volatile organic compounds and asthma. Dales R, Raizenne M. Journal of Asthma, 2004, 41:259–270.

Do indoor chemicals promote development of airway allergy? Nielsen GD et al. Indoor Air, 2007, 17:236–255.

IPEADAM study: indoor endotoxin exposure, family status, and some housing characteristics in English children. Tavernier G et al. Journal of Allergy and Clinical Immunology, 2006, 117:656–662.

Effects of volatile organic compounds, damp, and other environmental exposures in the home on wheezing illness in children. Venn AJ et al. Thorax, 2003, 58:955–960.

POLVO QUÍMICO

“Consumiendo química. Europa. Las sustancias peligrosas en el polvo doméstico, como indicador de exposición química en el hogar”. Greenpeace. Octubre 2003.

Sick of Dust. Chemicals in Common Products. A Needless Health Risk in Our Homes. Pat Costner, Beverley Thorpe & Alexandra McPherson. March 2005.

Semivolatile organic compounds in residential air along the Arizona-Mexico border. Gale et al. Environmental Science and Tecnology (2009) 43 (9): 3054-3060.

Phtalates, Alkylphenols, Pesticides, Polybrominated Diphenyl Ethers, and Other Endocrine-Disrupting Compounds in Indoor Air and Dust. Environmental Science & Technology, 37(20): 4543-4553. doi:10.1021/es0264596.

Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust. Rudel RA, Camann DE, Spengler JD, et al. Environ Sci Technol 2003;37:4543–53.

Phatalates in Indoor Dust and Their Association with Building Characteristics. Environmental Health Perspectives. 2005 October; 113(10): 1399–1404. Published online 2005 June 1. doi: 10.1289/ehp.7809

Wilson et al. (2003) Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home. Journ Expo Anal Environ Epidemiol; 13 (3): 187-202.

 

RESIDUOS DE PESTICIDAS EN LA COMIDA

The Collaborative on Health and the Environment. Toxicant and Diseases Database. Pesticides.

Breast cancer risk and the combined effect of environmental estrogens. Cancer Causes and Control 15: 591–600, 2004.

Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Anti-Androgens. Orton F, Rosivatz E, Scholze M, Kortenkamp A 2011. Environ Health Perspect :-. doi:10.1289/ehp.1002895

Plaguicidas en la dieta: aportando piezas al rompecabezas. Vicente A, et al. Gac Sanit 2004;18(6):425-30

Monitoring of Pesticide Residues in Products of Plant Origin in the EU, Norway , Iceland and Liechtestein. Commision of the European Communities. 2006

Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Rauh VA, Garfinkel R, Perera FP, et al. Pediatrics. 2006;118(6).

Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Eskenazi B, Marks AR, Bradman A, et al. Environ Health Perspect. 2007;115(5):792–798

Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children. Grandjean P, Harari R, Barr DB, Debes F. Pediatrics. 2006;117(3).

Long-term neurobehavioral health effects of methyl parathion exposure in children in Mississippi and Ohio. Ruckart PZ, Kakolewski K, Bove FJ, Kaye WE. Environ Health Perspect. 2004;112(1):46–51

Neurobehavioral performance in preschool children from agricultural and non-agricultural communities in Oregon and North Carolina. Rohlman DS, Arcury TA, Quandt SA, et al. Neurotoxicology. 2005;26(4):589–598.

Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides. Pediatrics Vol. 125 No. 6 June 2010, pp. e1270-e1277


CONTAMINANTES EN EL PESCADO

Recomendaciones de consumo de pescado (Pez Espada, Tiburón, Atún Rojo y Lucio) debido a la presencia de mercurio. Agencia Española de Seguridad Alimentaria y Nutrición.

Contaminación química por los alimentos más consumidos en Cataluña. Departamento de Salud de la Generalitat de Cataluña,  Laboratorio de Toxicología y Salud Medioambiental de la Universidad Rovira y Virgili, Unidad de Toxicología de la Facultad de Farmacia de la Universidad de Barcelona.

Exposure to PBDEs and PCDEs associated with the consumption of edible marine species. Domingo JL, Bocio A, Falcó G, Llobet JM (2006) Environ. Sci. Technol. (USA) 40, 4394-4399

Daily intake of arsenic, cadmium, mercury and lead by consumption of edible marine species.Falcó G, Llobet JM, Bocio A, Domingo JL (2006) J. Agric. Food Chem. (USA) 54, 6106-6112

Exposure to polycyclic aromatic hydrocarbons through consumption of edible marine species. Llobet JM, Falcó G, Bocio A, Domingo JL (2006) J. Food Prot. (USA) 69, 2493-2499

Human exposure to polychlorinated naphthalenes through the consumption of edible marine species. Llobet JM, Falcó G, Bocio A, Domingo JL (2007) Chemosphere (NL), 66, 1107-1113

Concentrations of PCDD/PCDFs and PCBs in fish and seafood from the Catalan (Spain) market: Estimated human intake. Bocio A, Domingo JL, Falcó G, Llobet JM (2007) Environ. Int. (UK), 33, 170-175

Benefits and risks of fish consumption. Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. Domingo JL, Bocio A, Falcó G, Llobet JM (2007) Toxicology, 230, 219-226

Benefits and risks of fish consumption. Part II. RIBEPEIX, a computer program to optimize the balance between the intake of omega-3 fatty acids and chemical contaminants. Domingo JL, Bocio A, Martí-Cid R, Llobet JM (2007) Toxicology, 230, 227-233

Exposure to hexachlorobenzene through fish and seafood consumption in Catalonia, Spain. Falcó G, Llobet JM, Bocio A, Nadal M, Domingo JL (2006) Organohalogen Compd., Vol 68, 1529-1531

Health risks arising from the dietary intake of chemical contaminants: a case study of the consumption of edible marine species in Catalonia, NE Spain. Josep L. Domingo. CONTRIBUTIONS to SCIENCE, 3 (4): 459–468 (2007) Institut d’Estudis Catalans; Barcelona. DOI: 10.2436/20.7010.01.22 ISSN: 1575-6343


EL PROBLEMA DE LOS UTENSILIOS DE COCINA, ENVASES, ETC.

Xenoestrogens released from lacquer coatings in food cans. Olea N et al. (1995).  Environmental Health Perspectives 103(6): 608-612.


PRODUCTOS DE ASEO PERSONAL Y COSMÉTICA

Endocrine active UV filters: developmental toxicity and exposure throught breast milk. Lichtensteiger W. et al. Chimia 62 (2008). 345-351

Scientific Committee on Cosmetic Products and Non-food Products. Opinion concerning a clarification on the formaldehyde and para-formaldehyde entry in Directive 76/768/EEC on cosmetic products. Opinion: European Commission. 2002.

Other uses of formaldehyde have different restrictions in Canada. For example, nail hardeners may contain concentrations equal to or less than 5% and oral care products may contain concentrations equal to or less than 0.1%. Formaldehyde is not permitted in aerosol cosmetics. See Canada’s Cosmetic Ingredient Hotlist, March 2007.

Meta-analysis of formaldehyde and hematologic cancers in humans. Zhang et al 2009. Mutation Research 681: 150-168.

U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. ”Formaldehyde (Gas) CAS No. 50-00-0: Reasonably anticipated to be a human carcinogen.” Eleventh Report on Carcinogens. December 2002.

Avoiding Formaldehyde Allergic Reactions In Children. Jacob SE and Steele T. Pediatric Annals 2007;36(1):55-6.

Threshold for occluded formaldehyde patch test in formaldehyde-sensitive patients. Relationship to repeated open application test with a product containing formaldehyde releaser. Flyvholm MA, Hall BM, Agner T, Tiedemann E, Greenhill P, Vanderveken W, Freeberg FE, Menné T. Contact Dermatitis. 1997;36(1):26-33.

Environmental Exposures – A pediatric perspective on allergic contact dermatitis. Jacob SE, Breithaupt A. Skin & Aging. July 2009: 28-36.

Formaldehyde-releasing preservative in baby and cosmetic products. Moennich JN, Hanna DM, Jacob SE (2009). Journal of the Dermatology Nurses’ Association 1:211-214.

Triclosan ,a commonly used bactericide found in human milk and in the acuatic environment in Sweden. Adolfsson-Erici M et al. Chemosfere 46: 1485-1489 .2002.

The effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats. Zorrilla, L., et al (2009).  Toxicological Sciences. 107(1) 56-64.

In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens. Ahn et al (2008). Environ Health Perspectives. 116(9): 1203–1210.

Triclosan and antimicrobial resistance in bacteria: An overview. Microbial Drug.  Yazdankhah, S.P., et al (2006). Resistance-Mechanisms Epidemiology and Disease. 12(2): 83-90

Photochemical conversion of triclosan to 2, 8-dichlorodibenzo-p-dioxin in aqueous solution. Latch D.E. Journal of Photochemistry and Photobiology A: Chemistry. 158: 63-66 (2003)Opinion on triclosan resistance adopted by the EU Scientific Steering Commitee meeting 27-28 June 2002

Urinary Concentrations of Triclosan in the U.S. Population: 2003–2004. Calafat, A., et al.  2008. Environ Health Perspect 116:303–307.

Cosmétiques et dermatitie dermatopique de lénfant. Les Nouvelles Dermatologiques. Pons-Guiraud A., 1994; 13-5: 409-414.

Occurrence of N-nitrosodiethanolamine (NDELA) in cosmetics from the Dutch market. Schothorst RC, Stephany RW. Int J Cosmet Sci. 2001 Apr;23(2):109-14.

N-Nitroso Compounds and Childhood Brain Tumors: A Case-Control Study. Susan Preston-Martin, Mimi C. Yu, Barbara Benton, and Brian E. Henderson Cancer Res December 1982 42; 5240

CIR (Cosmetic Ingredient Review Expert Panel) Final report on the safety assessment of t-butyl hydroquinone. 1986.Journal of the American College of Toxicology 5, pp. 329–351.

Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. Gomez, E., A. Pillon, et al. (2005). J Toxicol Environ Health A 68(4): 239-51.

CIR (Cosmetic Ingredient Review Expert Panel) Final report on the safety assessment of t-butyl hydroquinone, 1991. Journal of the American College of Toxicology 10, pp. 1–7.

Environmental Working Group. Skin Deep. Hydroquinone.

REAL DECRETO 1599/1997, DE 17 DE OCTUBRE, QUE RECOGE LA REGULACIÓN DE LOS PRODUCTOS COSMÉTICOS (BOE núm. 261, de 31 octubre [RCL 1997, 2572])

http://www.aemps.gob.es/legislacion/espana/cosmeticosHigiene/docs/Higiene/rcl_1997_2572.pdf

ORDEN SAS/3292/2009, DE 27 DE NOVIEMBRE, POR LA QUE SE MODIFICA EL ANEXO III DEL REAL DECRETO 1599/1997, DE 17DE OCTUBRE, SOBRE PRODUCTOS COSMÉTICOS. (BOE núm. 295, de 8 diciembre [RCL 2009, 2414])

http://www.aemps.gob.es/legislacion/espana/cosmeticosHigiene/docs/cosmeticos/rcl_2009_2414.pdf


PERFUMES

Peters ,RJB. (2005). Phtalates and artificial musks in perfumes. TNO Environment and Geosciences, Report R&T-A 2005-011. Para Greenpeace (accesible en la página web de la organización).

Opinion of the scientific commitee in cosmetic products and non-food products intended for consumers. An initial list of perfumery materials which must not form part of fragrances compounds used in cosmetic products. Adopted by the SCCNFP during the 12th Plenary meeting of 3 may 2000.

American Academy of Allergy , Asthma and Immunology: Today Findings from de AAAAI Annual Meeting unveil new research on allergic triggers and cutting-edge asthma treatments. March 4 .2000. 

Placebo-controlled challenges with perfume in patients with asthma like symptoms. Millqvist E and Lowhagen. Allergy 1996.  51(6): 434-439

Genetic an environmental factors associated with asthma. Bener A et al. Hum Bioi. 1996. 68 (39: 405-414

Fragranced Consumer Products and Undisclosed Ingredients. Steinemann AC. Environmental Impact Assessment Review 29(1): 32-38, 2009.

Prevalence of fragrance sensitivity in the American population. Caress SM, Steinemann, AC. J Environ Health 71(7):46-50, 2009.

Effect of odors in ashtma. Shim C and Williams MH. Am J Med 1986. 80(1): 18-22

Inhalation challenge effects of perfume strips in patients with asthma. Kumar P et al. Ann Allergy Asthma Inmunol. 1995. 75(5): 429-433

Cleaning products and air fresheners: exposure to primary and secondary air pollutants. Nazaroff WW, Weschler CJ. Atmos Environ 38(18):2841-65, 2004

Nitromusk compounds in women with gynecological and endocrine dysfunction. Eisenhardt S, Runnebaum B, Bauer K, Gerhard I. Environ Res. 2001 Dec;87(3):123-30.

Fragranced Consumer Products: Chemicals Emitted, Ingredients Unlisted. Steinemann AC, MacGregor IM, Gordon SM, Gallagher LG, Davis AL, Ribeiro DS, and Wallace LA. Environmental Impact Assessment Review, 2010.


PRODUCTOS DE LIMPIEZA

Indoor Air Chemistry: Cleaning Agents, Ozone and Toxic Air Contaminants. Final Report: Contract No. 01-336. Prepared for the California Air Resources Board and the California Environmental Protection Agency: California Air Resources Board Research Division. William W Nazaroff (principal investigator), Beverly K. Coleman, Hugo Destaillats, Alfred T. Hodgson, De-Ling Liu, Melissa M. Lunden, Brett C. Singer, and Charles J. Weschler. April 2006

Cleaning products and air fresheners : emissions and resulting concentrations of glycol ethers and terpenoids. Singer BC et al. Indoor air 2006. Jun 16 (3): 179-91

Cleaning products and air fresheners: exposure to primary and secondary air pollutants. William W. Nazaroff, Charles J. Weschler Atmospheric Environment. Volume 38, Issue 18, June 2004, Pages 2841–2865


AMBIENTADORES

Emission of chemicals by air fresheners. Test on 74 consumer products sold in Europe. January 2005. BEUC.

La Asociación Europea de Consumidores alerta de la presencia de sustancias cancerígenas en los ambientadores y productos de aromaterapia. 23 de los 32 productos estudiados por OCU en España son "muy malos" y deberían prohibirse.  22 de noviembre de 2004

SCIENTIFIC COMMITTEE ON HEALTH AND ENVIRONMENTAL RISKS. SCHER . Opinion on the report “Emission of chemicals by air fresheners Tests on 74 consumer products sold in Europe” (BEUC report January 2005). Adopted by the SCHER   during the 9th  plenary of 27 January 2006. European Commision.

Clearing the Air. Hidden Hazards of Air Fresheners. Alison Cohen et al. NRDC Issue Paper. September 2007

Full-Scale Chamber Investigation and Simulation of Air Freshener Emissions in the Presence of Ozone. Xiaoyu Liu , Mark Mason , Kenneth Krebs , and Leslie Sparks. Environ. Sci. Technol., 2004, 38 (10)

Emission measurements of selected volatile organic compounds in air with operating air fresheners, Muijser H, Nijssen LM, Duistermaat E, and Kersten JGThM TNO Report 6419. 2005

Mapping of chemical substances in air fresheners and other fragrance liberating products, Pors J, and Fuhlendorff R, 2003Danish Environmental Protection Agency, Survey no. 30.

Symptoms of mothers and infants related to total volatile organic compounds in household products. Farrow A, Taylor H, Northstone K, Golding J. Arch Environ Health. 2003 Oct;58(10):633-41.

Indoor fine particles: the role of terpene emissions from consumer products. Sarwar G, Olson DA, Corsi RL, Weschler CJ.J  Air Waste Manag Assoc. 2004 Mar;54(3):367-77.

Full-scale chamber investigation and simulation of air freshener emissions in the presence of ozone.  Liu X, Mason M, Krebs K, Sparks L. Environ Sci Technol. 2004 May 15;38(10):2802-12.

Toxic effects of air freshener emissions. Anderson RC, Anderson JH. Arch Environ Health. 1997 Nov-Dec;52(6):433-41.

Ventricular fibrillation following inhalation of Glade Air Freshener(TM) LoVecchio , F.*; Fulton  S.E.  European Journal of Emergency Medicine: June 2001 - Volume 8 - Issue 2 - pp 153-154. Case Report


PESTICIDAS DOMÉSTICOS

Impact of prenatal exposure to Piperonyl butoxide and Permethrin on 36-month neurodevelopment. Horton et al. Pediatrics 2011.

Reported Residential Pesticide Use and Breast Cancer Risk on Long Island, New York (American Journal of Epidemiology.2007. Vol 165. N 6.

http://fondosaludambiental.org/index.php?q=node/407

Pediatric Acute Lymphoblastic Leukemia and Exposure to Pesticides. Soldin O et al. Therapeutics drug monitoring. August 2009. Vol. 31 (4) : 495-501

Prohiben Clorpirifos; Diazinón; Diclorvos y Malatión

CHE Toxicant and Disease Database. Chlorpyrifos.

CHE Toxicant and Disease Database. Pyrethins / pyrethroids

CHE Toxicant and Disease Database. Permethrin

EPA announces plan to require disclosure of secret pesticide ingredients.

Inert Ingredients Permitted for Use in Nonfood Use Pesticide Products.  Last Updated April 2011

Unidentified Inert Ingredients in Pesticides: Implications for Human and Environmental Health. Environ Health Perspect 114:1803-1806. Cox C, Surgan M 2006.

SPRAYS

Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners. Zock JP, Kogevinas M, et al. (2001) Scandinavian Journal of Work , Environment & Health. Vol 27,nº1, 76-81

The Use of Household Cleaning Sprays and Adult Asthma. An International Longitudinal Study . Jan-Paul Zock, Estel Plana, Deborah Jarvis, Josep M. Antó, Hans Kromhout, Susan M. Kennedy, Nino Künzli, Simona Villani, Mario Olivieri, Kjell Torén, Katja Radon, Jordi Sunyer, Anna Dahlman-Hoglund, Dan Norbäck and Manolis Kogevinas.  American Journal of Respiratory and Critical Care Medicine Vol 176. pp. 735-741, (2007).


MATERIALES DE PAREDES Y TECHOS

NTP 521: Calidad de aire interior: emisiones de materiales utilizados en la construcción, decoración y mantenimiento de edificios.



RECUBRIMENTOS DE PAREDES

NTP 521: Calidad de aire interior: emisiones de materiales utilizados en la construcción, decoración y mantenimiento de edificios.


SUELOS

The association between asthma and allergic symptoms in children and phtalates in house dust: a nested case-control study. Bornehag CG et al. (2004). Environment Health Perspectives. 112 (14). 1393-1397

NTP 521: Calidad de aire interior: emisiones de materiales utilizados en la construcción, decoración y mantenimiento de edificios. INSHT


MOBILIARIO / MADERAS

NTP 521: Calidad de aire interior: emisiones de materiales utilizados en la construcción, decoración y mantenimiento de edificios.

NTP 466: Calidad del aire: determinación ambiental de formaldehído y medición de su contenido en tableros. Instituto Nacional de Seguridad e Higiene en el Trabajo.


PINTURA

NTP 521: Calidad de aire interior: emisiones de materiales utilizados en la construcción, decoración y mantenimiento de edificios.

 

AGUA CON TÓXICOS

Cloración del agua potable en España y cáncer de vejiga. Villanueva C.M,  Kogevinas M,  Grimalt J.O. (2001) Gaceta Sanitaria. 15 (01): 48-53 (Unitat de Recerca Respiratoria i Ambiental, IMIM; Instituto de Investigaciones Químicas y Ambientales de Barcelona. Departamento de Química Ambiental, CSIC).

Meta-analysis of studies in individual consumption of chlorinated drinking water and bladder cancer. Villanueva CM et al (2003). Journal of Epidemiology and Community Health 57: 166-173

Atención , agua no potable. Calidad y precio del agua en las capitales de provincia. OCU. Marzo de 2006.

Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review. Nieuwenhuijsen et al (2000) Occup Environ Med 57: 73-85

Relation between trihalomethane compounds and bird defects. Dodds L et al. (2001) Occup Environ Med. 58: 443-446 

Effect of trihalomethane exposure on fetal development. Wright JM et al (2003) Occupational and Environmental Medicine. 60: 173-180

Drinking water chlorination and adverse birth outcomes in Taiwan. Yang CY (2004) Toxicology 198: 249-254.

CHE Toxicant and Disease Database. Trihalomethanes.

Most Plastic Products Release Estrogenic Chemicals: A Potential Health Problem That Can Be Solved. Yang CZ, Yaniger SI, Jordan VC, Klein DJ, Bittner GD 2011. Environ Health Perspect 119:989-996.


ROPA

Textil y confección. ISTAS

"Tratamiento de textiles y sus repercusiones ambientales" Junio de 2005, Greenpeace.

Trapos sucios: Recarga. Las grandes marcas convierten a sus clientes en cómplices inconscientes del ciclo tóxico. 2011. Greenpeace

Comisión decisión 19 july 2001, establishing the ecological criteria for the award of the Community eco-label to hand dishwashing detergents. L214/30-42 Official Journal of the European Communities


ELECTRODOMÉSTICOS / ELECTRÓNICA

DIRECTIVA 2011/65/UE DEL PARLAMENTO EUROPEO Y DEL CONSEJO de 8 de junio de 2011 sobre restricciones a la utilización de determinadas sustancias peligrosas en aparatos  eléctricos y electrónicos (refundición) (Texto pertinente a efectos del EEE)

Total health assessment of chemicals in indoor climate from various consumer products. Survey of Chemical Substances in Consumer Products, No. 75 2006. Environmental Protection Agency. Danish Ministry of the Environment.

¿Jugando sucio? Análisis de sustancias químicas y materiales peligrosos en los componentes de videoconsolas Kevin Brigden, David Santillo y Paul Johnston.  Nota técnica 05/2008 de los Laboratorios de Investigación de Greenpeace. Mayo de 2008

Ranking Verde de Electrónicos. Greenpeace.


JUGUETES

Directiva 2005/84/CE  del Parlamento Europeo y del Consejo de 14 diciembre de 2005 por la que se modifica por vigesimosegunda vez la Directiva 76/769/CEE del Consejo relativa a la aproximación de las disposiciones legales, reglamentarias y administrativas de los Estados miembros que limitan la comercialización y el uso de determinadas sustancias y preparados peligrosos (ftalatos en los juguetes y artículos de puericultura).


ALGUNAS OTRAS COSAS

Directiva 2006/66/CE  del Parlamento Europeo y del Consejo, de 6 de septiembre de 2006, relativa a las pilas y acumuladores y a los residuos de pilas y acumuladores.

Directiva 2008/103/CE del Parlamento Europeo y del Consejo, de 19 de noviembre de 2008 , que modifica la Directiva 2006/66/CE, relativa a las pilas y acumuladores y a los residuos de pilas y acumuladores, por lo que respecta a la puesta en el mercado de pilas y acumuladores (Texto pertinente a efectos del EEE)

"Phthalates in school supplies", elaborado en 2008 por el CCRSM  (Comité científico de los riesgos sanitarios y medioambientales) de la Comisión Europea.

Toxicidad de la plastilina en función de su contenido de Cd, Cr, Pb,Ti, V, Fe y Mn posibles riesgos de su uso en la Educación Preescolar. José Ramón Domínguez, Ana María Varela, José Alvarado Durán. Revista de investigación, ISSN 1010-2914, Nº. 71, 2010 , págs. 237-248


CÁNCER

Environmental influences in cancer aetiology. Newby J.A. and Howard V. Journal of Nutritional & Environmental Medicine. 2006, 1-59. PrView article.

American Cancer Society. Cancer facts & Figures 2005. Accesible en www.cancer.org.

Ries LAG, et al. SEER Cancer statistics review, 1975-2001 table I-3 Bethesda, MD: National Cancer Institute- 2004, Accessed February 2005.

World Cancer Report. World Health Organization. 2003

CHE Toxicant and Disease Database. Breast cancer

State of the Evidence. What is the connection between the environment and breast cancer?. Sixth Edition 2010. Edited by Nancy Evans, Health Science Consultant. Breast Cancer Fund

Reported Residential Pesticide Use and Breast Cancer Risk on Long Island, New York. American Journal of Epidemiology. 2007. Vol 165. N 6

Self-reported chemicals exposure, beliefs about disease causation, and risk of breast cancer in the Cape Cod Breast Cancer and Environment Study: a case-control study. Environmental Health 2010, 9:40doi:10.1186/1476-069X-9-40

Perspectives on the Chemical Etiology of Breast Cancer. DeBruin L.S. and Josephy P.D. Environ Health Perspect 2002;110(Suppl 1):119-128.

Organic Solvents and Cancer. Lynge, E. et al. Cancer Causes and Control 1997;8:406-419.

Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Murray, TJ et al. Reprod Toxicol. 2006 Oct 24

Breast Cancer and the Environment. Solomon, G. Peer-reviewed report for Collaborative on Health and the Environment.

State of the Evidence. What is the connection between the environment and breast cancer?. Fourth Edition 2006. Edited by Nancy Evans, Health Science Consultant. Breast Cancer Fund.

Amercian Academy of Pediatrics, Committee on Environmental Health. Ambient Air Pollution: Health Hazards to Children. Pediatrics 2004; 114(6):1699-1707.

Health Effects of dioxin exposure: a 20-year mortality study. Bertazzi, P.A. et al. Am J Epidemiol 2001;153(11):1031-1044.

Organic Solvents and Cancer. Lynge, E. et al. Cancer Causes and Control 1997;8:406-419.

The carcinogenicity of acrylamide. Rice, JM. Mutat Res 2005; 580(1-2):3-20.

Trichloroethylene and Cancer: Epidemiologic Evidence. Wartenberg D. et al. Environ Health Perspect 2000;108(Suppl 2):161-176.

Collaborative on Health and the Environment. Solomon, G. Peer-reviewed analysis of childhood leukemia

Residential Pesticides and Childhood Leukemia: A Systematic Review and Meta-Analysis. M. C. Turner ET AL. Environ Health Perspect. 2010 January; 118(1): 33–41. Published online 2009 July 29. doi:  10.1289/ehp.0900966

Ma X. et al. Critical Windows of Exposure to Household Pesticides and Risk of Childhood Leukemia. Environ Health Perspect 2002;110(9):955-960.

Pediatric Acute Lymphoblastic Leukemia and Exposure to Pesticides. Soldin O et al. Therapeutics drug monitoring. August 2009. Vol. 31 (4) : 495-501.

The association between residential pesticide use and cutaneous melanoma. Cristina Fortes, Simona Mastroeni, Franco Melchi, Maria Antonietta Pilla, Massimo Alotto, Gianluca Antonelli, Diana Camaione, Simone Bolli, Elisabetta Luchetti, Paolo Pasquini. European Journal of Cancer. Volume 43, Issue 6 , Pages 1066-1075, April


PROBLEMAS REPRODUCTIVOS MASCULINOS

Schettler, T. Infertility and Related Reproductive Disorders. Peer-reviewed report for Collaborative on Health and the Environment

Semen Quality in Relation to Biomarkers of Pesticide Exposure. Swan, S.H. et al. Environ Health Perspect. 2003;111(12):1478-1484.

The relationship between environmental exposures to phtalates and DNA damage in human sperm using neutral comet assay. Duty SM, et al. (2003). Environmental Health Perspectives 11 (9): 1164-1169

National Toxicology Program Center for the Evaluation of Risks to Human Reproduction (NTP CERHR)

Phthalate Exposure and Human Semen Parameters. Duty, S.M. et al. Epidemiology 2003;14:269-77.

1998. Trends in sex-ratio, testicular cancer and male reproductive hazards: Are they connected? Møller, H. APMIS 106:232-23

Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Toft, G., et al. Reprod Toxicol, 2004. 19(1): p. 5-26.

Geographical differences in semen quality in a population of young healthy volunteers from the different regions in Spain. López Teijón et al. (2008) Andrología. Vol. 40. nº 5. 318-328.

Primer estudio de la fertilidad masculina en la provincia de Barcelona. 20 marzo 2004.

Relación entre la exposición a disruptores endocrinos durante el período fetal y perinatal y la tasa de oligospermia. Revista Internacional de Andrología, 9(2) (2011), 41-49

CHE Toxicant and Disease Database. Abnormal sperm (morphology, motility, and sperm count).

Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?. Sharpe, R and Skakkebaek N. Lancet 341: 1392-95 (1993)

Evidence for decreasing quality of semen during past 50 years. Skakkebeak N, et al. British Medical Journal 305: 609-13 (1992)

Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Anti-Androgens. Orton F, Rosivatz E, Scholze M, Kortenkamp A 2011. Environ Health Perspect.

Main et al. Flame Retardants in Placenta and Breast Milk and Cryptorchidism in Newborn Boys. Environmental Health Perspectives Vol. 115. Num. 10. oct 2007

Plasma Phthalate Levels in Pubertal Gynecomastia. Elif Ozmert et al. January 2010 Pediatrics.

CHE Toxicant and Disease Database. Reduced fertility - male (infertility and subfertility)

Epigenetic transgenerational actions of endocrine disruptors and male fertility.Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. 2005. Science, 308(5727): 1466-1469.

 Urinary phthalatemetabolites and semen quality: a review of a potential biomarker of susceptibility. Hauser R. Int J Androl. 2008 Apr;31(2):112-7. Epub 2007 Dec 6.

DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hauser R, Meeker JD, Singh NP, Silva MJ, Ryan L, Duty S, Calafat AM. Hum Reprod. 2007 Mar;22(3):688-95. Epub 2006 Nov 7.

Possible impact of phthalates on infant reproductive health. Lottrup G, Andersson AM, Leffers H, Mortensen GK, Toppari J, Skakkebaek NE, Main KM. Int J Androl. 2006 Feb;29(1):172-80; discussion 181-5.

Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Hauser R, Meeker JD, Duty S, Silva MJ, Calafat AM. Epidemiology. 2006 Nov;17(6):682-91.

Effects of bisphenol A on adult male mouse fertility. Al-Hiyasat, A.S., H. Darmani, and A.M. Elbetieha, Eur J Oral Sci, 2002. 110(2): p. 163-7.

Understanding the Human Health Effects of Chemical Mixtures. Carpenter D.O. et al. Environ Health Perspect 2002;110(suppl 1)25-42.

Occupational Exposures to Metals, Solvents, and Pesticides: Recent Evidence on Male Reproductive Effects and Biological Markers. Figa-Talamanca I. et al. Occup Med 2001;51(3):174-188.

Environmental Factors in Infertility. Hruska, K.S., et al., Clin Obstet Gynecol, 2000. 43(4): p. 821-829.

Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Ichihara, G. Int Arch Occup Environ Health. 2005 Mar;78(2):79-96.

Sanborn, MS. et al. Systematic Review of Pesticide Human Health Effects. Ontario College of Family Physicians. April, 2004.

Infertility and Related Reproductive Disorders. Schettler, T. Peer-reviewed report for Collaborative on Health and the Environment.

CHE Toxicant and Disease Database. Reproductive tract toxicity, male.

CHE Toxicant and Disease Database. Testicular toxicity.

Documentación toxicológica para el establecimiento del límite de exposición profesional del 2-etoxietanol y acetato de 2-etoxietilo. INSHT

Dibromuro de etileno. Hoja informativa sobre sustancias peligrosas. Estado de Nueva Jersey

Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Skakkebaek NE, Rajpert-De Meyts E, Main KM. Human Reprod2001;16:972–8.


INFERTILIDAD FEMENINA

Maternal levels of perfluorinated chemicals and subfecundity. Chunyuan Fei, Joseph K. McLaughlin, Loren Lipworth, and Jørn Olsen. Human Reproduction, Vol.1, No.1 pp. 1–6, 2009

Ethylene glycol ethers and risks of spontaneous abortion and subfertility. Correa, A., et al., Am J Epidemiol, 1996. 143(7): p. 707-717.

Mechanisms of phthalate ester toxicity in the female reproductive system. Lovekamp-Swan T, Davis BJ.Environ Health Perspect. 2003 Feb;111(2):139-45.

Reduced fertility among female wood workers exposed to formaldehyde. Taskinen HK, Kyyrönen P, Sallmén M, Virtanen SV, Liukkonen TA, Huida O, Lindbohm ML, Anttila A (1999) Am J Ind Med. 36:206–212.

Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. Choy, C.M et al. BJOG 2002; 109(10):1121-1125

DDT and DDE exposure in mothers and time to pregnancy in daughters. Cohn, B.A. et al. Lancet 2003;361:2205-2206.

CHE Toxicant and Disease Database.  Reduced fertility - female (infertility and subfertility)

Concordance across Species in the Reproductive and Developmental Toxicity of Tetrachloroethylene. Beliles, R.P. Toxicol Ind Health 2002;18:91-106.

Environmental Factors in Infertility. Hruska, K.S., et al., Clin Obstet Gynecol, 2000. 43(4): p. 821-829.

Reduced fertility among women exposed to organic solvents. Sallmen, M., et al., Am J Ind Med, 1995. 27(5): p. 699-713.

Infertility and Related Reproductive Disorders. Peer-reviewed report for Collaborative on Health and the Environment. Schettler, T.

Environmental toxicants and female reproduction. Sharara, F.I.et al.  Fertil Steril, 1998. 70(4): p. 613-22.

Environmental and occupational factors affecting fertility and IVF success. Younglai, E.V., A.C. Holloway, and W.G. Foster Hum Reprod Update, 2005. 11(1): p. 43-57.

High plasma concentrations of di-(2-ethyl-hexil)-phtalate in women with endometriosis. Corbellis L et al (2003) Hum Reproduction; 18 (7): 512-519

Dioxins and Endometriosis: A Plausible Hypothesis. Linda S. Birnbaum and Audrey M. Cummings. Environmental Health Perspectives • Volume 110 | Number 1 | January 2002.

Dioxin concentrations in women with endometriosis. Avigail Mayani et al. Human Reproduction (12) 1997

Serum Dioxin Concentrations and Endometriosis: A Cohort Study in Seveso, Italy. Brenda Eskenazi et al.  Environmental Health Perspectives • VOLUME 110 | NUMBER 7 | July 2002

Environmental PCB exposure and risk of endometriosis. G.M.Buck Louis et al. Human Reproduction Vol.20, No.1 pp. 279–285, 2005

Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis. Rier S. et al. 2001. Toxicol Sciences 59: 147-159


ASMA

Frequent use of chemical household products is associated with persistent wheezing in pre-school age children. A Sherriff, A Farrow, J Golding, the ALSPAC Study Team, J Henderson. Thorax 2005;60:45–49.

Atshma symptoms in hispanic children and daily ambient exposures to toxic and criteria air pollutants. Delfino RJ et al. (2003). Environmental Health Perspectives 111 (4): 647-656

The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Bornehag, CG. et al. Environ Health Perspect 2004; 112(14):1393-1397.

Asthma symptoms in women employed in domestic cleaning: a community based study. M Medina-Ramón, J P Zock1, M Kogevinas, J Sunyer, J M Antó.  Thorax 2003;58:950-954

The Use of Household Cleaning Sprays and Adult Asthma. An International Longitudinal Study. Jan-Paul Zock, Estel Plana, Deborah Jarvis, Josep M. Antó, Hans Kromhout, Susan M. Kennedy, Nino Künzli, Simona Villani, Mario Olivieri, Kjell Torén, Katja Radon, Jordi Sunyer, Anna Dahlman-Hoglund, Dan Norbäck and Manolis Kogevinas.  American Journal of Respiratory and Critical Care Medicine Vol 176. pp. 735-741, (2007)

Hazardous Air Pollutants and Asthma. Leikauf, G.D. Environ Health Perspect 2002;110(4):505-526.

Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners. Zock JP, Kogevinas M, et al. Scandinavian Journal of Work , Environment & Health. (2001) Vol 27,nº1, 76-81

Air pollution and health. Brunekeef B et al.  Lancet. 2002 Oct 19;360(9341):1233-42.

American Academy of Pediatrics, Committee on Environmental Health. Ambient Air Pollution: Health Hazards to Children. Pediatrics 2004; 114(6):1699-1707.

Plastic wall materials in the home and respiratory health in young children. Jaakkola JJ, Verkasalo PK, Jaakkola N. Am J Public Health 2000;90:797-9.

Asthma and the Environment. Peer-reviewed report for the Collaborative on Health and the Environment. Solomon, G.

Endocrine Disruptors and Asthma-Associated Chemicals in Consumer Products. Dodson, R.E., M. Nishioka, L.J. Standley, L.J. Perovich, J.G. Brody, R.A. Rudel. 2012. Environmental Health Perspectives, doi:10.1289/ehp.1104052


ALERGIAS

Methodological aspects and sample characteristics of the study. Caballero Martínez F.  Alergológica 2005. J Investig Allergol Clin Immunol. 2009;19 Suppl 2:2-6.

Common Household Chemicals and the Allergy Risks in Pre-School Age Children. Choi H, Schmidbauer N, Sundell J, Hasselgren M, Spengler J, et al. (2010) PLoS ONE 5(10): e13423. doi:10.1371/journal.pone.0013423

Children breathing fumes from water-based paints have high risk of asthma, allergies, new study says. Environmental Health News

Indoor residential chemical emissions as risk factors for respiratory and allergic effects in children: a review. M. J. Mendell. Indoor Air. Volume 17, Issue 4, pages 259–277, August 2007

The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Bornehag, CG. et al. Environ Health Perspect 2004; 112(14):1393-1397.

CHE Toxicant and Disease Database. Rhinitis – allergic

CHE Toxicant and Disease Database. Rhinitis – irritant

Enhanced interleukin-4 production in CD4+ T cells and elevated immunoglobulin E levels in antigen-primed mice by bisphenol A and nonylphenol endocrine disruptors. Involvement of nuclear factor.AT and Ca2+ . Lee et al (2003). Immunology; 109 (1): 76-86

The Impact of Bisphenol A and Triclosan on Immune Parameters in the US Population, NHANES 2003-2006. Clayton EMR, Todd M, Dowd JB, Aiello AE 2010. Environ Health Perspect :-. doi:10.1289/ehp.1002883

Di-(2-ethylhexyl) phtalate enhances atopic dermatitis-like skin lesions in mice. Takano et al (2006). Environmental Health Perspectives 114 : 1266-1269

Environment and the Skin. Suskin, R.R. Med Clin North Am 1990;74(2):307-324.

CHE Toxicant and Disease Database. Contact dermatitis – allergic

CHE Toxicant and Disease Database. Contact dermatitis - irritant

 

AUTOINMUNIDAD

Autoimmune Diseases Associated with Drugs, Chemicals, and Environmental Factors. D'Cruz, D. Toxicology Letters 2000; 112-113: 421-432.

Epidemiologic Studies of Environmental Agents and Systemic Autoimmune Diseases. Maves, M.D. Environ Health Perspect 1999;107(suppl 5):743-748.

Questions Persist: Environmental Factors in Autoimmune Disease. Schmidt CW 2011. Environ Health Perspect 119:a248-a253.

Is lipstick associated with the development of systemic lupus erythematosus (SLE)?. Wang J, Kay AB, Fletcher J, Formica MK, McAlindon TE. Clin Rheumatol. 2008 Sep;27(9):1183-7. Epub 2008 Jun 4.

Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana. USA. Pfau, JC. et al. Environ Health Perspect 2005;113(1):25-30.

Scleroderma and solvent exposure among women. Garabrant DH, Lacey JV Jr, Laing TJ, Gillespie BW, Mayes MD, Cooper BC, Schottenfeld D. Am J Epidemiol. 2003 Mar 15;157(6):493-500.

CHE Toxicant and Disease Database. Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

CHE Toxicant and Disease Database. Scleroderma

Mechanisms of disease: environmental factors in the pathogenesis of rheumatic disease. Gourley M, Miller FW. Nat Clin Practice Rheumatol 3(3):172–180. 2007. doi:10.1038/ncprheum0435

Environmental chemicals and autoimmune disease: cause and effect. Evelyn V Hess. Toxicology. Volumes 181–182, 27 December 2002, Pages 65–70

Occupational scleroderma-like disorder occurring in men engaged in the polymerization of epoxy resins. Yamakage A, Ishikawa H, Saito Y, Hattori A. Dermatologica. 1980;161(1):33–44.

Progressive systemic sclerosis sine scleroderma which developed after exposure to epoxy resin polymerization. Inachi S, Mizutani H, Ando Y, Shimizu M. J Dermatol. 1996 May;23(5):344–346.

Scleroderma, renal failure and death associated with exposure to urea formaldehyde foam insulation. Rush PJ, Chaiton A. J Rheumatol. 1986 Apr;13(2):475-6.

Review of the health effects of urea-formaldehyde foam insulation. L'Abbé KA, Hoey JR. Environ Res. 1984 Oct;35(1):246-63.

Health effects of urea formaldehyde foam insulation: evidence of causation. G R Norman and M T Newhouse CMAJ. 1986 April 1; 134(7): 733–738.

Progressive systemic sclerosis associated with exposure to trichloroethylene. Lockey JE, Kelly CR, Cannon GW, Colby TV, Aldrich V, Livingston GK. J Occup Med. 1987 Jun;29(6):493–496.

 

INMUNOSUPRESIÓN

Immunotoxicity of pesticides: a review. Blakley, B. et al. Toxicol Ind Health 1999;15:119-132.

Prenatal Immunotoxicant Exposure and Postnatal Autoimmune Disease. Holladay, S.D. Environ Health Perspect 1999; 107(suppl 5):687-691.

Epidemiologic Studies of Environmental Agents and Systemic Autoimmune Diseases. Maves, M.D. Environ Health Perspect 1999;107(suppl 5):743-748.

Developmental Considerations of Neurotoxic Exposures. Trask C.L. and Kosofsky B.E. Neurologic Clinics 2000; 18(3):541-562.

CHE Toxicant and Disease Database. Immune suppression.

ToxFAQs™ - Polibromobifenilos (Polybrominated Biphenyls). ATSDR


NEUROTOXICIDAD

Environmentally Related Disorders of the Cardiovascular System. Rosenman, K.D. Med Clin North Am 1990;74(2):361-375.

Pesticides and Human Health: A Resource for Health Professionals. A peer-reviewed report by Physicians for Social Responsibility (LA and Greater Bay Area chapters) and Californians for Pesticide Reform. Solomon G. et al. 2000.

CHE Toxicant and Disease Database.  Peripheral neuropathy

Exposure to home pesticides linked to Parkinson disease. Stephenson J. JAMA. 2000 Jun 21;283(23)

Residential pesticide exposure associated with risk of Parkinson's Disease. Stanford Report, May 10, 2000 http://news.stanford.edu/news/2000/may10/pesticide-510.html

Trichloroethylene and Parkinson disease. Zaheer F, Slevin JT. Neurol Clin. 2011 Aug;29(3):657-65. Epub 2011 Jul 7.

Solvent exposures and Parkinson disease risk in twins. S.M. Goldman. Annals of Neurology. Volume 71, Issue 6, pages 776–784, June 2012

Neurodegenerative Diseases and Exposure to Pesticides in the Elderly. Baldi I. et al. Am J Epidemiol 2003; 157(5): 409-414.

Whole-body lifetime occupational lead exposure and risk of Parkinson's disease. Environ Health Perspect. Coon, S et al. 2006 Dec;114(12):1872-6.

A possible association between exposure to n-hexane and parkinsonism. Vanacore, N. et al. Neurol Sci2000; 21(1):49-52.

CHE toxicant and Disease Database. Parkinson's disease / movement disorders.


HIPERSENSIBILIDAD

SQM. El riesgo tóxico diario. La Sensibilidad Química Múltiple y otras enfermedades que la química produce en cientos de miles de españoles. Carlos de Prada. F. Alborada 2008.

Toxicant induced loss of tolerance-an emerging theory of disease? Miller CS. Environ Health Perspect 105: 445-53. 1997

Empirical approaches for the investigation of toxicant – induced loss of tolerance. Miller C, Ashford N, Doty R,et al. Environ Health Perspect 1997; 105 (suppl 2): 515-9.

Model development and research vision for the future of multiple chemical sensitivity. Anetz BB. Scand J Environ Heath 25: 569-73. 1999. 

A National Population Study of the prevalence of Multiple Chemical Sensitivity. Caress S and Steinemann AC (2004) Archives of Environmental Health 59 (6).

Self reported chemical sensitivity in Germany: A population based survey. Hausteiner C, Bornschein S, Hansen J, Zilker T, Förstl H. International Journal of Hygiene and Environmental Health. Vol 208. Issue 4. 20 july 2005. 271-278.

CHE Toxicant and Disease Database. Pneumonitis (hypersensitivity)


INTOXICACIONES AGUDAS

Nociones generales de primeros auxilios. Protección Civil (contiene información útil sobre envenenamientos domésticos).

Intoxicaciones no farmacológicas. Joseba Rementería Radigales, Aitor Ruano López, Javier Humayor Yánez. Urgencias de Pediatría. Hospital de Basurto. Bilbao.

Productos de Limpieza y Mantenimiento de uso doméstico. Medidas de actuación en caso de accidente. SIT. Instituto Nacional de Toxicología. Madrid, 1996.

Información Toxicológica. Instituto Nacional de Toxicologia.

Memoria del Servicio de Información Toxicológica 2011.


FTALATOS

Phtalates and human health. Hauser, R. and Calafat A. M. Occup Environ Med 2005;62:806-818 doi:10.1136/oem.2004.017590

Phthalates in Indoor Dust and Their Association with Building Characteristics. Environ Health Perspect. 2005 October; 113(10): 1399–1404.Published online 2005 June 1.doi:10.1289/ehp.7809.

Prenatal exposures to ftalates among women in New York City and Krakow, Poland. Adibi JJ., Perera FP, et al. (2003Environmental Health Perspectives 11 (14): 1719-1722

Diethyl phtalate. Concise International Chemical Assesstment Document 52. WHO (2003) Geneva. ISBN 92_4- 15052-9 (LC/NLM Classification: QV 612), ISSN 1020-6167)..

Urinary levels of seven phtalate metabolites in the US population  from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Silva MJ et al. Environmental Health Perspectives 112 (3): 331-338) .

The association between phthalates in dust and allergic diseases among Bulgarian children. Kolarik B, Naydenov K, Larsson M, Bornehag CG, Sundell J. Environ Health Perspect. 2008 Jan;116(1):98-103.

The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Bornehag CG, Sundell J, Weschler CJ, Sigsgaard T, Lundgren B, Hasselgren M, Hägerhed-Engman L. Environ Health Perspect. 2004 Oct;112(14):1393-7.

Phthalate levels in Norwegian indoor air related to particle size fraction. Rakkestad KE, Dye CJ, Yttri KE, Holme JA, Hongslo JK, Schwarze PE, Becher R. J Environ Monit. 2007 Dec;9(12):1419-25. Epub 2007 Sep 7.

Pollutants in house dust as indicators of indoor contamination. Butte W, Heinzow B. Rev Environ Contam Toxicol. 2002;175:1-46.

The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysis. Jaakkola JJ, Knight TL. Environ Health Perspect. 2008 Jul;116(7):845-53.

Levels of pollutants in indoor air and respiratory health in preschool children: a systematic review. Fuentes-Leonarte V, Tenías JM, Ballester F. Pediatr Pulmonol. 2009 Mar;44(3):231-43.

Human exposure to phthalates via consumer products. Schettler T. Int J Androl. 2006 Feb;29(1):134-9; discussion 181-5.

Exposure to Di(2-ethylhexyl)phthalate in humans during pregnancy. A preliminary report. Latini, G., C. De Felice, et al. (2003). Biol Neonate 83(1): 22-4.

Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Main, K. M., G. K. Mortensen, et al. (2006). Environ Health Perspect 114(2): 270-6.

Phthalate exposure and male infertility. Latini G, Del Vecchio A, Massaro M, Verrotti A, De Felice C. Toxicology. 2006 Sep 21;226(2-3):90-8. Epub 2006 Jul 15.

The relationship between environmental exposures to phtalates and DNA damage in human sperm using neutral comet assay. Duty SM, et al. (2003)Environmental Health Perspectives 11 (9): 1164-1169

Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Colon I, Caro D, Bourdony CJ, et al. Environ Health Perspect2000;108.

Phthalate exposure and early thelarche. McKee RH. Environ Health Perspect 2004;112

The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Duty SM, Singh NP, Silva MJ, et al Environ Health Perspect2003;111

Phthalate exposure and human semen parameters. Duty SM, Silva MJ, Barr DB, et al. Epidemiology2003;14

The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parameters. Duty SM, Calafat AM, Silva MJ, et al. J Androl2004;25

Phthalate exposure and reproductive hormones in adult men. Duty SM, Calafat AM, Silva MJ, et al. Human Reprod2005;20

Phthalate-esters and semen quality parameters. Murature DA, Tang SY, Steinhardt G, et al. Biomedical and Environmental Mass Spectrometry1987;14

Role of environmental estrogens in the deterioration of male factor fertility. Rozati R, Reddy PP, Reddanna P, et al Fertility & Sterility2002;78:1187–94.

Time to pregnancy among partners of men exposed to di(2- ethylhexyl)phthalate. Modigh CM, Bodin SLV, Lillienberg L, et al. Scand J Work Environ Health2002;28:418–28.

Human Breast Milk Contamination with Phthalates and Alterations of Endogenous Reproductive Hormones in Infants Three Months of Age.  K. M. Main et al. Environmental Health Perspectives 114 (2006)

Altered Semen Quality in Relation to Urinary Concentrations of Phthalate Monoester and Oxidative Metabolites R. Hauser et al.  Epidemiology 17, no. 6 (2006)

The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parameters. Duty, S. M., A. M. Calafat, et al. (2004). J Androl 25(2): 293-302.

Phthalate exposure and reproductive hormones in adult men. Duty, S. M., A. M. Calafat, et al. (2005). Hum Reprod 20(3): 604-10.

Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust. Rudel RA, Camann DE, Spengler JD, et al. Environ Sci Technol 2003;37:4543–53.

Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure . Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL (August 2005). Environ. Health Perspect. 113 (8): 1056–61

Environmental effects on hormonal regulation of testicular descent. Toppari J, Virtanen H, Skakkebaek NE, Main KM (2006). J Steroid Biochem Mol Biol 102 (1–5): 184–6.

Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, et al. The Study for Future Families Research Team 2005. Environ Health Perspect 113:1056-1061. http://dx.doi.org/10.1289/ehp.8100

Prenatal phthalate exposure and reduced masculine play in boys. S. H. Swan,  F. Liu1, M. Hines, R. L. Kruse, C. Wang, J. B. Redmon, A. Sparks, B. Weiss.International Journal of Andrology  Article Volume 33, Issue 2, pages 259–269, April 2010. First published online: 16 NOV 2009. Special Issue: Proceedings of the 5th Copenhagen Workshop on Endocrine Disrupters, 20-22 May 2009

Plasma Phthalate Levels in Pubertal Gynecomastia. Elif Ozmert, M.D., Ph.D., Hacettepe University, Ankara, Turkey; and Sheela Sathyanarayana, M.D., assistant professor of pediatrics, University of Washington, Seattle; January 2010 Pediatrics.

PPAR-mediated activity of phthalates: A link to the obesity epidemic?. Desvergne B, Feige J, Casals-Casas C (2009). Mol Cell Endocrinol. 304 (1–2): 43–8.

Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Teitelbaum SL, Mervish N, Moshier EL, Vangeepuram N, Galvez MP, Calafat AM, Silva MJ, Brenner BL, Wolff MS. 2012. Environ Res 112:186-193.

Phthalate, Environmental Chemical Is Linked to Higher Rates of Childhood Obesity. ScienceDaily (June 26, 2012)

Concentrations of Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. Males. Richard W. Stahlhut, Edwin van Wijngaarden, Timothy D. Dye, Stephen Cook, and Shanna H. Swan. Environ Health Perspect. 2007 June; 115(6): 876–882.

Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children. Kim BN, Cho SC, Kim Y, Shin MS, Yoo HJ, Kim JW, Yang YH, Kim HW, Bhang SY, Hong YC. Biol Psychiatry. 2009 Nov 15;66(10):958-63. Epub 2009 Sep 12.

Relationship between environmental phthalate exposure and the intelligence of school-age children. Cho SC, Bhang SY, Hong YC, Shin MS, Kim BN, Kim JW, Yoo HJ, Cho IH, Kim HW. Environ Health Perspect. 2010 Jul;118(7):1027-32. Epub 2010 Mar 1.

Phthalate Levels and Low Birth Weight: A Nested Case-Control Study of Chinese Newborns. Yunhui Zhang, Ling Lin, Yang Cao,  Bingheng Chen, Lixing Zheng, Ren-Shan Ge. The Journal of Pediatrics. Volume 155, Issue 4 , Pages 500-504, October 2009

Prenatal Phthalate Exposure Is Associated with Childhood Behavior and Executive Functioning. Engel SM, Miodovnik A, Canfield RL, Zhu C, Silva MJ, Calafat AM, Wolff MS (2010). Environ. Health Perspect. 2010 Jan 8

Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age. Whyatt RM, Liu X, Rauh VA, Calafat AM, Just AC, Hoepner L, et al. 2012. Environ Health Perspect 120:290-295. http://dx.doi.org/10.1289/ehp.1103705

Exposure to phthalates and breast cancer risk in Northern Mexico.Lopez-Carillo, L., Hernandez-Ramirez, R.U., Calafat, A.M., Torres-Sanchez, L., Galvan-Portillo, M., Needham, L.L., Ruiz-Ramos, R., & Cebrian, M.E.(2010). Environmental Health Perspectives, 114 (4), 539-544.

Estimation of estrogenic and antiestrigenic activities of some phtalate diesters and monoesters by MCF-7 cell proliferation assay in vitro. Okubo T et al (2003). Biol Pharm Bull; 26 (8): 1219-1224

Legado Químico. Contaminación en la infancia. Catherine N. Doney, PhD .

Identification of ftalate esters in the serum of young Puerto Rican girls with premature breast developtment. Colon et al. (2000). Environmental  Health Perspectives; 108 (9): 895-900.

Prenatal Di(2-ethylhexyl)Phthalate Exposure and Length of Gestation Among an Inner-City Cohort. [Journal Article]. Whyatt RM, Adibi JJ, Calafat AM, Camann DE, Rauh V, Bhat HK, Perera FP, Andrews H, Just AC, Hoepner L, Tang D, Hauser R. Pediatrics 2009. Dec; 124(6):e1213-20.

Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City. Meeker JD, Hu H, Cantonwine DE, Lamadrid-Figueroa H, Calafat AM, Ettinger AS, et al. 2009. Environ Health Perspect 117:1587-1592.

Adjuvant and immuno-supresive effect of six monophtalates in a subcutaneous injection model with BALB/c mice, Larsen ST et al. (2001) Toxicology: 169 (1) :37-51

High plasma concentrations of di-(2-ethyl-hexul)-phtalate in women with endometriosis. Corbellis L et al (2003) Hum Reproduction; 18 (7): 512-519

Phthalate exposure associated with self-reported diabetes among Mexican women. Svensson K, Hernández-Ramírez RU, Burguete-García A, Cebrián ME, Calafat AM, Needham LL, Claudio L, López-Carrillo L. Environ Res. 2011 Aug;111(6):792-6. Epub 2011 Jun 21.

The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysis. Jaakkola JJ, Knight TL. Environ Health Perspect. 2008 Jul;116(7):845-53.

Phthalic esters in the indoor environment--test chamber studies on PVC-coated wallcoverings. Uhde E, Bednarek M, Fuhrmann F, Salthammer T. Indoor Air. 2001 Sep;11(3):150-5.

Phthalate exposure and pulmonary function. Hoppin JA, Ulmer R, London SJ. Environ Health Perspect 2004;112:571–4.

Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway.Jaakkola JJ, Oie L, Nafstad P, Botten G, Samuelsen SO, Magnus P.  Am J Public Health. 1999 Feb;89(2):188-92.

Plastic wall materials in the home and respiratory health in young children. Jaakkola JJK, Verkasalo PK, Jaakkola N. Am J Public Health2000;90:797–9.

Plastic wall materials in the home and respiratory health in young children. Jaakkola JJK, Verkasalo PK, Jaakkola N. Am J Public Health2000;90:797–9.

Ventilation in homes and bronchial obstruction in young children. Oie L, Nafstad P, Botten G, et al. Epidemiology1999;10:294–9.

Synthetic bedding and wheeze in childhood. Ponsonby AL, Dwyer T, Kemp A, et al. Epidemiology2003;14:37–44.

NTP-CERHR expert panel report on di (2-ethylhexyl) phthalate (DEHP), Center for the Evaluation of Risks to Human Reproduction. CERHR (2000).

 

COMPUESTOS PERFLUORADOS

Estimating consumer exposure to PFOS and PFOA. Trudel D, Horowitz L, Wormuth M, Scheringer M, Cousins IT, Hungerbühler K. Risk Anal. 2008

Maternal levels of perfluorinated chemicals and subfecundity. Chunyuan Fei, Joseph K. McLaughlin, Loren Lipworth, and Jørn Olsen. Human Reproduction, Vol.1, No.1 pp. 1–6, 2009

The developmental toxicity of perfluoroalkyl acids and their derivatives. Lau C, Butenhoff JL, Rogers JM (2004).Toxicol Appl Pharmacol 198:231–241.

Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort. Fei CY, McLaughlin JK, Tarone RE, Olsen J (2007) Environ Health Perspect 115:1677–1682.

Perfluoroalkyl acids: a review of monitoring and toxicological findings. Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J (2007) Toxicol Sci 99:366–394.

The toxicology of perfluorooctanoate. Kennedy GL, Butenhoff JL, Olsen GW, O'Connor JC, Seacat AM, Perkins RG, Biegel LB, Murphy SR, Farrar DG. Crit. Rev. Toxicol. 2004;34:351-384

Sustancias perfluoroalquiladas (PFOA y PFOS).

Analytical method  for PFOA (and higher homologues) in articles  - challenges and current status.

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey.Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS, 2010 Environ Health Perspect 118(5): doi:10.1289/ehp.0901584

Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives. Olsen GW, Butenhoff JL, Zobel LR. Reprod Toxicol. 2009 Jun;27(3-4):212-30. Epub 2009 Feb 20.

Self-reported health effects among community residents exposed to perfluorooctanoate. Anderson-Mahoney P, Kotlerman J, Takhar H, Gray D, Dahlgren J. New Solut. 2008;18(2):129-43.

Thyroid Function and Perfluoroalkyl Acids in Children Living Near a Chemical Plant. Lopez-Espinosa M-J, Mondal D, Armstrong B, Bloom MS, Fletcher T 2012. Environ Health Perspect 120:1036-1041.

Maternal levels of perfluorinated chemicals and subfecundity. Fei C, McLaughlin JK, Lipworth L, Olsen J. Hum Reprod. 2009 May;24(5):1200-5. Epub 2009 Jan 28.

Agency for Toxic Substances and Disease Registry (ATSDR). 2009. Toxicological profile for Perfluoroalkyls (Draft for Public Comment). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Toxic Substances Portal – Perfluoroalkyls. ATSDR.

Perfluoroalkyl Acids: What Is the Evidence Telling Us? Betts KS 2007. Environ Health Perspect 115:A250-A256. http://dx.doi.org/10.1289/ehp.115-a250

Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts Scientific Opinion of the Panel on Contaminants in the Food chain [1]

Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project. Frisbee SJ, Shankar A, Knox SS, Steenland K, Savitz DA, Fletcher T, Ducatman AM. Arch Pediatr Adolesc Med. 2010 Sep;164(9):860-9.

Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H,Kishi R. Environ Health Perspect. 2009 Apr;117(4):660-7. Epub 2008 Nov 4.

Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age. Hoffman K, Webster TF, Weisskopf MG, Weinberg J, Vieira VM. Environ Health Perspect. 2010 Dec;118(12):1762-7. Epub 2010 Jun 15.

Perfluorochemical (PFC) exposure in children: Associations with impaired response inhibition. Gump, BB, Q Wu, AK Dumas and K Kannan. 2011. Environmental Science and Technology.

Perfluorochemicals: Potential sources of and migration from food packaging. Begley, TH, K White, P Honigfort, ML Twaroski, R Neches and RA Walke. 2005. Food Additives and Contaminants 22(10):1023-1031.

Perfluoroalkyl compounds (PFCs) in indoor dust: Concentrations, human exposure estimates, and sources. Bjorklund, JA, K Thuresson and CA De Wit. 2009. Environmental Science and Technology 43:2276-2281.

Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort. Fei C, McLaughlin JK, Tarone RE, Olsen J. Environ Health Perspect. 2007 Nov;115(11):1677-82.

Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant. Lopez-Espinosa MJ, Fletcher T, Armstrong B, Genser B, Dhatariya K, Mondal D, Ducatman A, Leonardi G. Environ Sci Technol. 2011 Oct 1;45(19):8160-6. Epub 2011 May 2.

Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults. Lin CY, Lin LY, Chiang CK, Wang WJ, Su YN, Hung KY, Chen PC. Am J Gastroenterol. 2010 Jun;105(6):1354-63. Epub 2009 Dec 15.

Perfluorochemicals in pooled serum samples from United States residents in 2001 and 2002. Calafat, A. M., Z. Kuklenyik, et al. (2006). Environ Sci Technol 40(7): 2128-34.

The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years. Harada, K., N. Saito, et al. (2004). J Occup Health 46(2): 141-7

Environmental and toxicity effects of perfluoroalkylated substances. Hekster, F. M., R. W. Laane, et al. (2003). Rev Environ Contam Toxicol 179: 99-121.

Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy. Inoue, K., F. Okada, et al. (2004). Environ Health Perspect 112(11): 1204-7.

Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Kannan, K., S. Corsolini, et al. (2004). Environ Sci Technol 38(17): 4489-95.

Levels of 12 perfluorinated chemicals in pooled australian serum, collected 2002-2003, in relation to age, gender, and region. Karrman, A., J. F. Mueller, et al. (2006). Environ Sci Technol 40(12): 3742-8.

 

ALMIZCLES SINTÉTICOS

Hazardous chemicals in precipitations. Peters TJB. (2003). TNO report R2003/198, commissioned by Greenpeace Netherlands.

Emerging contaminants –pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in acuatic organisms. Smital T et al. (2004). Mutation research 552 (1-2): 101-117

Bioaccumulation and ecotoxicity of synthetic musks in the acuatic environment. Dietrich DR and Hitzfeld BC (2004) Chapter in : GC Rimkus (d) Synthetic musk fragrances in the environment, Springer-Verlag  Berlin  ISBN 3.540-43706-1

The interference of nitro- and polycyclic musks with endogenous and xenobiotic metabolizing enzymes in carp: an in vitro study. Schnell S, Martin-Skilton R, Fernandes D, Porte C. Environ Sci Technol. 2009 Dec 15;43(24):9458-64.

In vitro an in  vivo antiestrogenic effects of polyciclic musks in zebrafish. Schreurs RH et al. (2004). Environmental Science and Technology 38 (4): 997-1002.

Estrogenic activity of musk fragrances detected by the e-screen assay in human MCF-7 cells. Bitsch N et al. (2002). Archives of Environmental Contamination and Toxicology 43 (3): 257-264

Musk ketone enhances benzo(a)pirene induced mutagenicity in human derived Hep G2 cells. Merch-Sundermann et al (2001). Mut Research; 495 (1-2): 89-96

Transcriptional activation of estrogen receptors ERf an ERg by polyciclic musks in cell type dependents. Schreurs RH et al. (2002). Toxicology and Applied Pharmacology 183 (1):1-9

Nitromusk compounds in women with gynaecological and endocrine dysfunction. Eisenhardt S et al. (2001)- Environmental Research 87 (3): 123-130

SCCNFP 2002a. Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning 6-Acetyl-1,1,2,4,4,7-Hexamethyl-tetraline (AHTN). SCCNFP/0609/02.

Blood concentrations of polycyclic musks in healthy young adults. Hutter, H. P., P. Wallner, et al. (2005). Chemosphere 59(4): 487-92

Polycyclic musk compounds in higher trophic level aquatic organisms and humans from the United States. Kannan, K., J. L. Reiner, et al. (2005). Chemosphere 61(5): 693-700.

Irreversible effects of neonatal exposure to p-tert-octylphenol on the reproductive tract in female rats. Katsuda, S., Yoshida, M., Watanabe, G., Taya, K., Maekawa, A., (2000). Toxicol Appl Pharmacol 165(3): 217-26.

Dose- and treatment duration-related effects of p-tert-octylphenol on female rats. Katsuda, S., M. Yoshida, et al. (2000). Reproductive Toxicology 14(2): 119-126.

Polyciclic musk fragrances in human adipose tissue and human milk. Rimkus GC. And Wolf M.(1996). Chemosphere 33(10): 2033-2043

 Nitro musks in human adipose tissue and breast milk. Rimkus G et al. (1994). Chemosphere. 28: 421-423

 Nitromusk and polycyclic musk compounds as long-term inhibitors of cellular xenobiotic defense systems mediated by multi-drug transporters. Luckenbach T, Epel D. Environ Health Perspect. 2005;113:17–24.

The Role of Musk and Musk Compounds in the Fragrance Industry. Rimkus, Gerhard G. (Ed.); Cornelia Sommer (2004Synthetic Musk Fragrances in the Environment (Handbook of Environmental Chemistry)

Temporal trends of synthetic musk compounds in mother’s milk and associations with personal use of perfumed products. Lignell S, Darnerud PO, Aune M, Cnattingius S, Hajslova J, Setkova L, Glynn A. 2008. Environ Sci Technol. 42(17): 6743-8

Ingredients for the Modern Perfumery Industry. The Chemistry of Fragrances (2nd ed.). Chapter 4. Charles (Ed.), Sell; Charles Sell (2005). Royal Society of Chemistry Publishing.

Environmental Working Group (EWG) 2009. Pollution in Minority Newborns.

Eau de tóxicos. Una investigación de químicos en perfumes. ANÁLISIS QUÍMICO DE 36 AGUAS DE COLONIA Y PERFUMES. Informe 2005. Greenpeace.

Synthetic Musk Fragrances in the Environment. The Handbook of Environmental Chemistry, Part 3X. Rimkus, Gerhard G. (Ed.)2004, XIV, 338 p. 56 illus.

Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B. 2005. Toxicol Sci. 83(2): 264-72.

Acute hepatotoxicity of the polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphtaline (AHTN). Steinberg P, Fischer T, Arand M, Park E, Elmadfa I, Rimkus G, Brunn H, Dienes HP. (1999). Toxicol Lett.,111(1-2), pp151-60.

Estrogenic activity of musk fragrances detected by the E-screen assay using human mcf-7 cells. Bitsch N, Dudas C, Körner W, Failing K, Biselli S, Rimkus G, Brunn H. 2002. Arch Environ Contam Toxicol. 43(3): 257-64.

1-(5,6,7,8-TETRAHYDRO-3,5,5,6,8,8-HEXAMETHYL-2-NAPHTHYL)ETHAN-1-ONE (AHTN) European Union Risk Assessment Report. 2008. CAS No: 1506-02-1 or 21145-77-7.

Human toxome project/chemicals/Polycyclic Musks. EWG.

Campaing for Safe Cosmetics. Synthetic Musks.

Reglamento (CE) n° 1223/2009 del Parlamento Europeo y del Consejo, de 30 de noviembre de 2009, sobre los productos cosméticos (Texto pertinente a los efectos del EEE).

Synthetic Musks. Campaing for Safe Cosmetics.

 

HIDROCARBUROS AROMÁTICOS POLICÍCLICOS

Promoting actions for healthy indoor air (IAIAQ). Directorate General for Health and Consumers. 2011.

The German Environmental Survey 1990/1992 (GerES  II): sources of personal exposure to volatile organic compounds. Hoffmann K et al. Journal of Exposure Analysis and Environmental Epidemiology, 2000,10:115–125

ToxFAQs™ - Hidrocarburos aromáticos policíclicos (HAPs) [Polycyclic Aromatic Hydrocarbons (PAHs)]. ATSDR

Resúmenes de Salud Pública - Naftalina, 1-metilnaftalina, 2-metilnaftalina (Naphthalene, 1-Methylnaphthalene, 2-Methylnaphthalene). ATSDR

DIRECTIVA 2011/71/UE DE LA COMISIÓN de 26 de julio de 2011 por la que se modifica la Directiva 98/8/CE del Parlamento Europeo y del Consejo de forma que incluya la creosota como sustancia activa en su anexo I

2002/59/CE: Decisión de la Comisión, de 23 de enero de 2002, sobre el proyecto de disposiciones nacionales notificadas por el Reino de los Países Bajos en aplicación del apartado 5 del artículo 95 del Tratado CE que limitan la comercialización y el uso de la madera tratada con creosota (Texto pertinente a efectos del EEE) [notificada con el número C(2002) 97]

Aproximación a la problemática de la Creosota

Creosota de Madera, Creosota de Alquitrán de Hulla y Alquitrán de Hulla. Resumen de Salud Pública. ATSDR.

Polycyclic aromatic hydrocarbons in indoor and outdoor  environments and factors affecting their concentrations. Ohura T et al. Environmental  Science and Technology, 2004, 38:77–83

Monitoring of environmental exposure to polycyclic aromatic hydrocarbons: a review.  Srogi K. Environmental Chemistry Letters, 2007, 5:169–195.

Polycyclic Aromatic Hydrocarbons in indoor and outdoor environments and factors affecting their concentrations. Ohura T et al. Environmental Science & Technology, 2004, 38:77–83

Chemosphere. 2003 Feb;50(5):673-9.

Generation rates and emission factors of particulate matter and particle-bound polycyclic aromatic hydrocarbons of incense sticks.

Contribution of incense burning to indoor PM10 and particle-bound polycyclic aromatic hydrocarbons under two ventilation conditions. Lung SCC et al. Indoor Air, 2003, 13:194–199.

Levels of selected organic compounds in materials for candle production and human exposure to candle emissions. Lau C et al. Chemosphere, 1997, 34:1623–1630.

Polycyclic aromatic hydrocarbons in residential air of ten Chicago area homes: concentrations and influencing factors. Li A et al. Atmospheric  Environment, 2005, 39:3491–3501

 

PLOMO

Opinion on Voluntary Risk Assessment Report on  lead and lead compounds. Human Health Part. Lead. Scientific Committee on Health and Environmental Risks  SCHER. European Commission. 2009.

Lead Standard in Drinking Water. Scientific Committee on Health and Environmental Risks  SCHER. European Commission.2011.

Voluntary Risk Assessment Report on lead and some inorganic lead compounds – Human Health section.  Report prepared by ILZRO and EBRC Consulting under contract to the LDAI Lead Risk Assessment Working Group. VRAR (2008).

NIEHS.

Lead in paint, dust and soil. EPA

Lead In Your Home: A Parents Reference Guide. EPA.

La toxicidad del plomo.¿Dónde se encuentra el plomo?. ATSDR.

Plomo. Fuentes de exposición pediátrica a plomo en España. PEHSU.

US Children’s Lead Exposures, 2008: Implications for Prevention. Levin R, Brown M, Kashtock M, Jacobs D, Whelan E, Rodman J, et al. 2008. Environmental Health Perspectives Online 19 May; doi:10.1289/ehp.11241.

Understanding international crime trends: The legacy of preschool lead exposure. Rick Nevin. Environmental Research. Volume 104, Issue 3, July 2007, Pages 315–336

Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age. Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, Canfield RL. Environ Health Perspect. 2008;116:243–248

Elevated blood lead levels and blood screening among US children aged 1–5 years: 1988–1994. Kaufmann RB, Clouse TL, Olson DR, Matte TD. Pediatrics. 2000;106(6):79–86

Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. Wright JP et al. Public Library of Science.  Medicine. May 2008. Vol 5. Issue 5. 732-740

Bone lead levels in adjudicated delinquents: a case control study. Needleman et al.(2002). Neurotoxicol Teratol 24: 711-717

Bone lead levels and delinquent behavior. Needleman HL et al. (1996). JAMA 275: 363-369

 Primary prevention of lead exposure: the Philadelphia lead safe homes study. Campbell C, Tran M, Gracely E, Starkey N, Kersten H, Palermo P, Rothman N, Line L, Hansen-Turton T. Public Health Rep. 2011 May-Jun;126 Suppl 1:76-88.

Window Replacement and Residential Lead Paint Hazard Control 12 Years Later. Dixon S, Jacobs DE, Wilson J, Akoto J, Clark CS. Environmental Research, on-line Feb 15, 2012.

Lead exposures from varnished floor refinishing. Shirmer J, Havlena J, Jacobs DE, Dixon S, Ikens R.  Journal of Occupational and Environmental Hygiene. Accepted Dec, 2011.

Exposure of U.S. children to residential dust lead, 1999-2004: II. The contribution of lead-contaminated dust to children's blood lead levels. Dixon SL, Gaitens JM, Jacobs DE, Strauss W, Nagaraja J, Pivetz T, Wilson JW, Ashley PJ. Environmental Health Perspectives 117(3):468-74, 2009

Exposure of U.S. children to residential dust lead, 1999-2004: I. Housing and demographic factors. Gaitens JM, Dixon SL, Jacobs DE, Nagaraja J, Strauss W, Wilson JW, Ashley PJ Environmental Health Perspectives 117(3):461-467, 2009

Validation of a Twenty-Year Forecast of U.S. Childhood Lead Poisoning: Updated Prospects for 2010, Jacobs DE and Nevin R. Environmental Research 102(3) 352-364, Nov 2006

Lead-contaminated drinking waters in the public schools of Philadelphia. Bryan SD. J Toxicol Clin Toxicol. 2004;42(3):287–294.

Occurrence and determinants of increases in blood lead levels in children shortly after lead hazard control activities. Clark S, Grote J, Wilson J, Succop P, Chen M, Galke W, et al. Environ Res. 2004;96(2):196–205.

The contribution of lead-contaminated house dust and residential soil to children’s blood lead levels: a pooled analysis of 12 epidemiological studies. Lanphear BP, Matte T, Rogers J, Clickner R, Dietz B, Bornschein R, et al. Environ Res. 1998;79:51–56.

Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. Environ Health Perspect. 2002;110:721–728.

Do the same houses poison many children? An investigation of lead poisoning in Rochester, New York, 1993–2004. Korfmacher KS, Kuholski K. Public Health Rep. 2007;122(4):482–487.

Lead levels of edibles grown in contaminated residential soils: a field survey. Finster ME, Gray KA, Binns HJ. Sci Total Environ. 2004;320(2–3):245–257.

Factors affecting the leaching of lead from UPVC pipes. Koh LL, Wong MK, Gan LM, Yap CT Environ Monit Assess. 1991;19:203–214.

Estimation of lead intake from crystal ware under conditions of consumer use. Guadagnino E, Gambaro M, Gramiccioni L, Denaro M, Feliciani R, Baldini M, et al Food Addit Contam. 2000;17(3):205–218.

Lead poisoning from souvenir earthenware. Hellstrom-Lindberg E, Bjorklund A, Karlson-Stiber C, Harper P, Selden AI. Int Arch Occup Environ Health. 2006;79(2):165–168

Lead stabilized uPVC potable pipe: extraction results under NSF standard number 61. Mitchener GR -J Vinyl Addit Technol. 1992;14(1):16–19.

Childhood lead poisoning and vinyl miniblind exposure. Norman EH, Hertz-Picciotto I, Salmen DA, Ward TH. Arch Pediatr Adolesc Med. 1997;151(10):1033–1037

Identifying housing that poisons: a critical step in eliminating childhood lead poisoning. Reyes NL, Wong LY, MacRoy PM, Curtis G, Meyer PA, Evens A, et al. J Public Health Manag Pract. 2006;12:563–569.

CHE. Toxicant and Disease Database- Lead.

 

MERCURIO

Toxicant and Disease Database. The Collaborative on Health and the Environment. Mercury.

Mercury flows in Europe and the world:  The impact of decommissioned chlor-alkali plants. February 2004. EUROPEAN COMMISSION DIRECTORATE GENERAL FOR ENVIRONMENT

Freno a las cremas contaminadas con mercurio. El Mundo. 8.3.2012.

Salud Publica y Medio Ambiente. Preguntas frecuentes: el mercurio y la salud. Octubre de 2011. OMS

Communication from the Commission of 28 January 2005: “Community Strategy concerning Mercury” [COM(2005) 20  final – Official Journal C 52 of 2 March 2005].

Study on the potential for  reducing mercury pollution from dental amalgam and batteries. Draft final report. European Commission-DG Env. 5 March 2012.

Mercury. What's new?. A stakeholders meeting on mercury in dental amalgam and batteries was organised in Brussels on 26 March 2012.

European Commission falls behind on EU Mercury Strategy. PRESS RELEASE, Brussels, 10th December 2010.

Mercury in Certain Energy-saving Light Bulbs. SCHER (Scientific Committee on Health and Environmental Risks).European Commission. 2010.

Prenatal mercury exposure in a multicenter cohort study in Spain. Ramon R, Murcia M, Aguinagalde X, Amurrio A, Llop S, Ibarluzea J, Lertxundi A, Alvarez-Pedrerol M, Casas M, Vioque J, Sunyer J, Tardon A, Martinez-Arguelles B, Ballester F. Environ Int. 2011 Jan 14.

Exposición infantil a contaminantes ambientales en Granada y posibles efectos en salud. Carmen Freire Warden, departamento de Radiología y Medicina Física de la UGR. (Tesis Univ. Granada. Departamento de Radiología y Medicina Física. Leída el 15 de mayo de 2009.)

 

RETARDANTES DE LLAMA

Phthalates, Alkylphenols, Pesticides, Polybrominated Diphenyl Ethers, and Other Endocrine-Disrupting Compounds in Indoor Air and Dust. Environmental Science & Technology, 37(20): 4543-4553. doi:10.1021/es0264596.

Indoor contamination with hexabromocyclododecanes, polybrominated diphenyl ethers, and perfluoroalkyl compounds: An important exposure pathway for peoble? Harrad S, de Wit C, Abdallah MA-E, Bergh C, Björklund JA, Covaci A, Darnerud PO, de Boer J, Diamond M, et al. 2010. Environ Sci Technol 44:3221-3231.

San Antonio Statement on Brominated and Chlorinated Flame Retardants. Apoyada por el Panel Internacional sobre Contaminación Química (IPCP).

Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend syudy, 1972-1997. Meironyte et al. (1999) J Toxicol Environ Health A; 58 (6):329-341.

Polybrominated diphenyl ethers in maternal and fetal blood samples. Mazdai, A., N. G. Dodder, et al. (2003). Environ Health Perspect 111(9): 1249-52

A review on human exposure to brominated flame retardants--particularly polybrominated diphenyl ethers. Sjodin, A. (2003). Environ Int 29(6): 11

Temporal trends of polybrominated diphenyl ethers and hexabromocyclododecane in milk from Stockholm mothers, Fängström B, Athanassiadis I, Odsjö T, Noren K, Bergman Å. 2008. 1980-2004. Mol Nutr Food Res 52:187-193.

Current State of Knowledge and Monitoring requirements: Emerging “New” brominated flame retardants in flame retarded products and the environment. Harju M, Heimstad ES, Herzke D, Sandanger T, Posner S, Wania F. 2009. Norwegian Pollution Control Authority Report 2462.

Human prenatal and post natal exposure to polybrominated diphenyl ethers, plyclorinated byphenils and pentachlorophenol. Guvenius et al. (2003). Environ Health Perspect; 111 (9): 1235-1241.

Risk assessment hexabromocyclododecane, Final report May 2008. European Commission.

Brominated and chlorinated organic chemical compounds used as flame retardants. OEHHA (Office of Environmental Health Hazard Assessment). 2008.

A perspective on the potential health risks of PBDEs. McDonald, T. A. (2002). Chemosphere 46: 11

Polybrominated diphenylether levels among United States residents: daily intake and risk of harm to the developing brain and reproductive organs. McDonald, T. A. (2005). Integr Environ Assess Manag 1(4): 343-54.

Thyroid Insult: Flame Retardants Linked to Alterations in Pregnant Women’s TSH Levels. Betts KS 2010. Environ Health Perspect 118:a445-a445.

PBDE Flame Retardants and Thyroid Hormones during Pregnancy. Goodman JE, Kerper LE, Johnson GT, Harbison RD, Cordero R, Lee RV, et al. Hardy M, Stedeford T 2010. Environ Health Perspect 118:a520-a520.

Brominated flame retardants: a novel class of developmental neurotoxicants in our environment?. Eriksson P. et al. (2001) Environ Health Perspect . 109: 903-908.

Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality. K. Akutsu, S. Takatori, S. Nozawa, M. Yoshiike, H. Nakazawa, K. Hayakawa, T. Makino and T. Iwamoto. Bulletin of Environmental Contamination and Toxicology. Volume 80, Number 4, 345-350, DOI: 10.1007/s00128-008-9370-4

Polybrominated Diphenyl Ethers (PBDEs) and Hexabromocyclodecane (HBCD) in Composite U.S. Food Samples. Schecter A, Haffner D, Colacino J, Patel K, Päpke O, et al. 2009 Environ Health Perspect 118(3): doi:10.1289/ehp.0901345

A perspective on the potential health risks of PBDEs. McDonald TA. 2002. Chemosphere 46:745–755

 PBDE Concentrations in Women's Serum and Fecundability. Harley KG, Marks AR, Chevrier J, Bradman A, Sjödin A, Eskenazi B (2010). Environ Health Perspect 118 (5): 699–704. doi:10.1289/ehp.0901450 . PMC 2866688. PMID 20103495.

Polybrominated Diphenyl Ether (PBDE) Flame Retardants and Thyroid Hormone during Pregnancy. Chevrier J, Harley KG, Bradman A, Gharbi M, Sjödin A, Eskenazi B (2010Environ Health Perspect 118 (10): 1444–1449. doi:10.1289/ehp.1001905 . PMC 2957927. PMID 20562054.

Prenatal Exposure to PBDEs and Neurodevelopment. Herbstman JB, Sjödin A, Kurzon M, Lederman SA, Jones RS, Rauh V, Needham LL, Tang D et al. (2010). Environ Health Perspect 118 (5): 712–719. doi:10.1289/ehp.0901340 . PMC 2866690. PMID 20056561.

Polybrominated diphenyl ethers: neurobehavioral effects following developmental exposure. Branchi, I., F. Capone, et al. (2003Neurotoxicology 24(3): 449-62.

Prenatal Exposure to Organohalogens, Including Brominated Flame Retardants, Influences Motor, Cognitive, and Behavioral Performance at School Age. Roze E, Meijer L, Bakker A, Van Braeckel KN, Sauer PJ, Bos AF (2009Environ Health Perspect 117 (12): 1953–1958. doi:10.1289/ehp.0901015 . PMC 2799472. PMID 20049217.

Flame Retardants in Placenta and Breast Milk and Cryptorchidism in Newborn Boys. Main et al. Environmental Health Perspectives Vol. 115. Num. 10. oct 2007

PBDEs in 2- 5-year-old children from California and associations with diet and indoor environment. Rose, M; Bennett, DH; Bergman, A; Fängström, B; Pessah, IN; Hertz-Picciotto, I (2010). Environ. Sci. Technol 44 (7): 2648–2653. doi:10.1021/es903240g . PMID 20196589.

Toxic Substances Portal - Polybrominated Diphenyl Ethers (PBDEs). ATSDR

Do Polybrominated Diphenyl Ethers (PBDEs) Increase the Risk of Thyroid Cancer? Yawei Zhang, Grace L. Guo, Xuesong Han, Cairong Zhu, Briseis A. Kilfoy, Yong Zhu, Peter Boyle, and Tongzhang Zheng. Biosci Hypotheses. 2008; 1(4): 195–199.

Effects of Decabrominated Diphenyl Ether (PBDE-209) in Regulation of Growth and Apoptosis of Breast, Ovarian, and Cervical Cancer Cells. Li Z-H, Liu X-Y, Wang N, Chen J-S, Chen Y-H, et al. 2012 Environ Health Perspect 120(4): doi:10.1289/ehp.1104051

Burdens of PBBs, PBDEs, and PCBs in tissues of the cancer patients in the e-waste disassembly sites in Zhejiang, China. Zhao GF, Wang ZJ, Zhou HD, Zhao Q. 2009. Sci Total Environ 407(17):4831–4837.

Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Silberhorn EM, Glauert HP, Robertson LW. Crit Rev Toxicol. 1990;20(6):440-96.

Review on human exposure to brominated flame retardants--particularly polybrominated diphenyl ethers. Sjodin A, Patterson DG, Jr, Bergman AA. Environ Int. 2003;29:829–39.

DIRECTIVE 2003/11/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 6 February 2003 amending for the 24th time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances and preparations (pentabromodiphenyl ether, octabromodiphenyl ether). http://eur-lex.europa.eu/LexUriServ/site/en/oj/2003/l_042/l_04220030215e... .

Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice. Fowles JR, Fairbrother A, Baecher-Steppan L, Kerkvliet NI. Toxicology. 1994;86:49–61

Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Zhou T, Taylor MM, DeVito MJ, Crofton KM. Toxicol Sci. 2002;66:105–16.

Polybrominated Diphenyl Ethers. Breast Cancer Fund.

Molecular mechanisms underlying proliferation and apoptosis in breast cancer MCF-7 cells induced by pentabrominated diphenyl ethers. Yu L, Zhan P (2009b). Toxicol Environ Chem, 91:665-670.

Chronic postnatal DE-71 exposure: effects on learning, attention and thyroxine levels. Driscoll LL, et al. Neurotoxicol Teratol 31(2):76–84. 2009.

Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects. Kodavanti PRS, et al. Toxicol Sci 116(1):297–312. 2010.

Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system. Dingemans MML, et al. Environ Health Perspect 119(7):900–907. 2011.

Polybrominated diphenyl ethers as endocrine disruptors of adipocyte metabolism. Hoppe AA, Carey GB. Obesity. 15(12):pp. 2945–2950.

Association of brominated flame retardants with diabetes and metabolic syndrome in the U.S. population, 2003–2004. Lim J-S, et al. Diabetes Care 31(9):1802–1807. 2008. http://dx.doi.org/10.2337/dc08-0850

Halogenated flame retardants: Does the benefit justify the risk? Keynote address: 6th Annual Early Enviornmental Exposures Conference of the Breast Cancer and the Environment Research Centers, Sausalito, CA. Birnbaum LS (2009).

Co-exposure to a polybrominated diphenyl ether (PBDE 99) and an orthosubstituted PCB (PCB 52) enhances developmental neurotoxic effects. Eriksson, P.; Fischer, C.; Fredriksson, A. 2003. Organohalogen Compounds. (61):81-83.

 Conference presentation : Examining the Potential Health Risks Posed by PBDEs: nvironmental Finance Center, Brominated Flame Retardants and Foam Furniture Conference and Roundtable, San Francisco. April 29, 2003. McDonald, T. 2003.

Polybrominated diphenyl  ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Hallgren, S.; Darnerud, P.O. 2002. Toxicology. (177):227-43

Mother's Milk: Health risks of PBDEs

ToxFAQs™ - Polibromobifenilos (Polybrominated Biphenyls). ATSDR

http://www.atsdr.cdc.gov/es/toxfaqs/es_tfacts68.html

Why is it So Difficult to Choose Safer Alternatives for Hazardous Chemicals?. Brown VJ, 2012 Environ Health Perspect 120(7): doi:10.1289/ehp.120-a280

Toxic effects of brominated flame retardants in man and in wildlife. Darnerud, P. O. (2003). Environ Int 29(6): 13.

Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Darnerud, P. O., G. S. Eriksen, et al. (2001). Environ Health Perspect 109 Suppl 1: 49-68

Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study. Fischer, D., K. Hooper, et al. (2006). Environ Health Perspect 114(10): 1581-4.

Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians. Jakobsson, K., K. Thuresson, et al. (2002). Chemosphere 46(5): 709-16.

Neonatal exposure to higher brominated diphenyl ethers, hepta-, octa-, or nonabromodiphenyl ether, impairs spontaneous behavior and learning and memory functions of adult mice. Viberg H, J. N., Fredriksson A, Eriksson J, Marsh G, Eriksson P. (2006). Toxicol Sci 92(1): 9.

 

ALQUILFENOLES

Alkylphenol xenoestrogens with varying carbon chain lengths differentially and potently activate signaling and functional responses in GH3/B6/F10 somatomammotropes. Kochukov, Y.; Jeng, J.; Watson, S. (May 2009). Environmental health perspectives 117 (5): 723–730.

Environmental fate of alkylphenols and alkylphenol ethoxylates—a review. Guang-Guo Yinga , Brian Williams, Rai Kookana. Environment International. Volume 28, Issue 3, July 2002, Pages 215–226

Estrogenic effects of effluents from sewage treatment works. Purdom, C, et al. Chemistry and Ecology 8: 275-85 (1994).

 Detergent components in sewage effluent are weakly oestrigenic to fish: an in vitro study using Rainbow trout (Oncorhynchus mykiss) hepatocytes. Jobling S et al. Aquatic Toxicology 27: 361-72 (1993)

ENDS (1999), Plastic contaminate tap water with hormone disrupters. The ENDS Report (243): 4-5.

Endocrine disrupting nonylphenols are ubiqutous in food. Guenther et al. Environ Science and Technology. 36 (8): 1676-80.

Bisphenol A and nonylphenols in human umbilical cords. Takada et al. (1999). Proceedings of the International Scientific Conference on Environmental Endocrine Disrupting Chemicals. Monte Verita, Ascona (Suiza). 7-22 March 1999.

Human toxome project/chemicals/Alkylphenols. EWG. http://www.ewg.org/sites/humantoxome/chemicals/chemical_classes.php?clas...

Estrogen-like response to p-nonylphenol in human first trimester placenta and BeWo choriocarcinoma cells. Bechi, N. (2006). Toxicol Sci 93(1): 6.

 Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. Diel P., Olff S., Schmidt S., Michna H. (2002). J Steroid Biochem Mol Biol 80(1): 10.

Indoor air pollution by alkylphenols in Tokyo. Saito I, Onuki A, Seto H. Indoor Air. 2004 Oct;14(5):325-32.

Determination and residual characteristic of alkylphenols in household food detergents of Taiwan. Pan YP, Tsai SW. Chemosphere. 2009 Jul;76(3):381-6. Epub 2009 Apr 16.

Determination of alkylphenol residues in baby-food purees by steam distillation extraction and gas chromatography-mass spectrometry. Li CT, Cheng CY, Ding WH. Food Chem Toxicol. 2008 Feb;46(2):803-7. Epub 2007 Sep 19.

Measurement of 4-nonylphenol and 4-tertoctylphenol in human urine by column-switching liquid chromatography-mass spectrometry.  Inoue K, K. M., Okada F, Takai N, Yoshimura Y, Horie M, (2003). Anal Chim Acta 486: 10.

Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population. Antonia M. Calafat, Z. K., John A. Reidy, Samuel P. Caudill, John Ekong, Larry L. Needham (2005). Environmental Health Perspectives 113(4): 5.

Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Boockfor, F. R. and C. A. Blake (1997). Biol Reprod 57(2): 267-77.

Environmental levels of para-nonylphenol are able to affect cytokine secretion in human placenta. Bechi N, Ietta F, Romagnoli R, Jantra S, Cencini M, Galassi G, Serchi T, Corsi I, Focardi S, Paulesu L. Environ Health Perspect. 2010 Mar;118(3):427-31.

Review article: Nonylphenol in the environment: A critical review on occurrence, fate, toxicity and treatment in wastewaters.  A. Soares, B. Guieysse, B. Jefferson, E. Cartmell, J.N. Lester Environment International 2008, Volume 34, Pages 1033-1049

DIRECTIVE 2003/53/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 18 June 2003 amending for the 26th time Council Directive 76/769/EEC relating to restrictions on the marketing and use of certain dangerous substances and preparations (nonylphenol, nonylphenol ethoxylate and cement), European Union. EU (2003).

Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Laws, S. C., S. A. Carey, et al. (2000). Toxicol Sci 54(1): 154-67.

Toxic  effects of octylphenol on cultured rat spermatogenic cells and Sertoli cells. Raychoudhury, S. S., Blake, C. A., Millette, C. F. (1999). Toxicol Appl Pharmacol 157(3): 192-202.

Acute hepatotoxicity of the polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphtaline (AHTN). Steinberg, P., T. Fischer, et al. (1999). Toxicol Lett 111(1-2): 151-60

Occupational leukoderma from alkyl phenols. C D Calnan. Proc R Soc Med. 1973 March; 66(3): 258–260.

CHE Toxicant and Disease Database » alkyl phenols

Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Sharpe et al. (1995). Environmental health Perspectives; 103 (12): 1136-1143

CHE Toxicant and Disease Database » octylphenol

 

BISFENOL A

Bisphenol A and nonylphenols in human umbilical cords. Takada et al. (1999). Proceedings of the International Scientific Conference on Environmental Endocrine Disrupting Chemicals. Monte Verita, Ascona (Suiza). 7-22 March 1999.

Parent bisphenol A accumulation in the human maternal-fetal-placental unit. Schonfelder et al. (2002) Environmental Health Perspectives 110 (11) A 703-707.

Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing , boiling and brushsing. Brede , C (2003). Food Addit Contam; 20 (7): 684-689.

Determination of bisphenol A in, and its migration from, PVC stretch film used for food packaging. López Cervantes J y Paseiro Losada P (2003). Food Addit Contam. 20

Estrogen receptor-mediated  effects of a xenoestrogen , bisphenol-A, on preimplantation mouse embyos. Takai et al (2000). Biochem Biophys Res Commun; 270 (3): 918-921. 

Preimplantation exposure to bisphenol A advances postnatal development. Takai et al (2001). Reprod Toxicol ; 15 (1): 71-74

In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Markey CM et al. (2001) Biol reprod; 65 : 1215-1223

Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Murray, T. J., M. V. Maffini, et al. (2006). Reprod Toxicol.

Estrogenicity of resin-based composites and sealants used in dentistry. Olea, N., R. Pulgar, et al. (1996). Environ Health Perspect 104(3): 298-305.

Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice. Palanza, P. L., K. L. Howdeshell, et al. (2002). Environ Health Perspect 110 Suppl 3: 415-22

Early exposure to a low dose of bisphenol A affects socio-sexual behavior of juvenile female rats. Porrini, S., V. Belloni, et al. (2005). Brain Res Bull 65(3): 261-6.

Bisphenol A affects spermatogenesis in the adult rat even at low doses. Sakaue, M., S. Ohsako, et al. (2001). Journal of Occupational Health 43: 185-190.

In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vagina. Schonfelder, G., B. Flick, et al. (2002). Neoplasia 4(2): 98-102.

Exposure to bisphenol A is associated with recurrent miscarriage. Sugiura-Ogasawara, M., Y. Ozaki, et al. (2005). Hum Reprod 20(8): 2325-9.

Associattion of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. Lang Al et al (2008) Journ Am Med Assoc 300 (11) 1303-1310

Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. Melzer D et al.  PLoS One. 2012;7(8):e43378. Epub 2012 Aug 15.

Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R, Khaw KT, Wareham NJ, Galloway TS. Circulation. 2012 Mar 27;125(12):1482-90. Epub 2012 Feb 21.

Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS. PLoS One. 2010 Jan 13;5(1):e8673.

Urinary Bisphenol A (BPA) Concentration Associates with Obesity and Insulin Resistance

Tiange Wang et al. JCEM ONLINE: Brief reports

Determinations of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Ikezuki Y et al (2002) Human Reprod; 17: 2839-2841

Endocrine Disruptors and Polycystic Ovary Syndrome (PCOS): Elevated Serum Levels of Bisphenol A in Women with PCOS. E. Kandaraki. A.Chatzigeorgiou, S. Livadas, E. Palioura, F. Economou, M. Koutsilieris, S. Palimeri, D. Panidis, E. Diamanti-Kandarakis. Journal of Clinical Endocrinology & Metabolism,2010  

 Serum bisphenol A concentrations showed gender differences, possibly linked to androgen levels. -Takeuchi T y Tsutsumi O (2002). Biochem Biophys Res Commun; 291 (1): 76-78

Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Yamada et al (2002). Reprod Toxicol; 16 (6): 735-739

Exposure to bisphenol A advances puberty. Howdeshell KL et al. (1999). Nature; 401 (6755): 763-764

Endocrine disruptors and reproductive health: the case of bisphenol-A. Maffini M.V., R. B. S., Sonnenschein C., Soto A.M. (2006). Mol Cell Endocrinol 254-255: 8.

An Extensive New Literature Concerning Low-Dose Effects of Bisphenol A Shows the Need for a New Risk Assessment. Vom Saal, F. and C. Hughes (2005). Environmental Health Perspectives 113(8): 926-933.

A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Vom Saal, F. S., P. S. Cooke, et al. (1998). Toxicol Ind Health 14(1-2): 239-60.

The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells. Wetherill, Y. B., C. E. Petre, et al. (2002). Mol Cancer Ther 1(7): 515-24.

 

FORMALDEHIDO

Formaldehyde Exposure and Asthma in Children: A Systematic Review. McGwin, G; Lienert, J; Kennedy, JI (November 2009). Environmental health perspectives (Environmental Health Perspectives) 118 (3) (3): 313–7.

Formaldehyde exposure and Leukemia: A New Meta-Analysis and Potential Mechanisms. 681 (2–3). Mutation Research/Reviews in Mutation Research. March–June 2009. pp. 150–168.

Formaldehyde and Leukemia: Epidemiology, Potential Mechanisms, and Implications for Risk Assessment. 51. Environmental and Molecular Mutagenesis. 2010. pp. 181–191

Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. Hauptmann M, Lubin JH, Stewart PA, Hayes RB, Blair A. J Natl Cancer Inst. 2003 Nov 5;95(21):1615-23.

CHE Toxicant and Disease Database. Formaldehyde.

Sostenibilidad en España 2006. Observatorio para la Sostenibilidad en España (OSE). Exposición a sustancias químicas peligrosas

REAL DECRETO 665/1997, de 12 de mayo, sobre la protección de los trabajadores contra los riesgos relacionados con la exposición a agentes cancerígenos durante el trabajo. BOE nº 124 24/05/1997

 Indoor air chemistry. Cleanig agents, ozone and toxic air contaminants. Final report: Contract N0 01-336. Prepared for the California Air Resources Board and the California Environmental Protection Agency. Nazaroff et al. (2006).

 Fichas Internacionales de Seguridad Química. Formaldehído. ICSC: 0275. NºCAS 50-00-0 International Chemical Safety Cards (WHO/IPCS/ILO). www.mtas.es USA)

ToxFAQswww.atsdr.cdc.gov  TM. Formaldehído. ATSDR (Agency for Toxic Substances & Disease Registry. Departament of Health and Human Services.

Common Ingredients in U.S. Licensed Vaccines. July 7, 2011

Indoor Air Pollution in California. Air Resources Board, California Environmental Protection Agency. July 2005. pp. 65–70.

Formaldehyde and Indoor Air. Health Canada. August 2005

European Union Bans formaldehyde/formalin within Europe" (PDF). European Commission's Environment Directorate-General. September 2007. pp. 1–3.

Quality of indoor residential air and health. Dales, R; Liu, L; Wheeler, AJ; Gilbert, NL (July 2008). Canadian Medical Association Journal (Canadian Medical Association Journal) 179 (2) (2): 147–52.

Asthmatic symptoms and volatile organic compounds, formaldehyde, and carbon dioxide in dwellings. Norbäck D, Björnsson E, Janson C, et al. Occup Environ Med 1995;52:388-95

Asthma and the indoor environment: the significance of emission of formaldehyde and volatile organic compounds from newly painted indoor surfaces. Wieslander G, Norbäck D, Björnsson E, et al. Int Arch Occup Environ Health 1997;69:115-24.

Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers. De Groot, Anton C; Flyvholm, Mari-Ann; Lensen, Gerda; Menné, Torkil; Coenraads, Pieter-Jan (2009). Contact Dermatitis 61 (2): 63–85

Formaldehyde and Facts About Health Effects (PDF). Formaldehyde Epidemiology, Toxicology and Environmental Group. August 2002.

Formaldehyde: an experimental multipotential carcinogen. Soffritti M, Maltoni C, Maffei F, Biagi R. Toxicol Ind Health. 1989;5:699–730.

Formaldehyde. In: Formaldehyde, 2-butoxyethanol and 1-tertbutoxypropan-2-ol. Lyon, International Agency for Research on Cancer,

2006:39–325 (IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 88).

Hazardous Substances Data Bank (HSDB) [online database]. Bethesda, MD, National Library of Medicine, 2010.

Formaldehyde in the indoor environment. Salthammer T, Mentese S, Marutzky R Chemical Reviews, 2010, 110:2536–2572.

Emission rates of formaldehyde from materials and consumer products found in California homes. Kelly TJ, Smith DL, Satola J. Environmental Science & Technology, 1999, 33:81–88.

Sources of formaldehyde, other aldehydes and terpenes in a new manufactured house. Hodgson AT, Beal D, McIlvaine JER. Indoor Air, 2002, 12:235–242

Cleaning products and air fresheners: exposure to primary and secondary air pollutants. Nazaroff WW, Weschler CJ. Atmospheric Environment, 2004, 38:2841–2865.

Airway response to formaldehyde inhalation in asthmatic subjects with suspected respiratory formaldehyde sensitization. Krakowiak A et al. American Journal of Industrial Medicine, 1998, 33:274–281.

Effect of formaldehyde on asthmatic responses to inhaled allergen challenge. Ezratty V et al. Environmental Health Perspectives, 2007, 115:210–214.

Pulmonary function and bronchial reactivity in asthmatics during low-level formaldehyde exposure. Harving H et al. Lung, 1990, 168:15–21.

Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms. Kriebel D et al. Archives of Environmental Health, 2001, 56:11–18.

Health effects of a mixture of indoor air volatile organics, their ozone oxidation products, and stress. Fiedler N et al. Environmental Health Perspectives, 2005, 113:1542–1548.

Asthma and the indoor environment: the significance of emission of formaldehyde and volatile organic compounds from newly painted indoor surfaces. Wieslander G et al. International Archives of Occupational and Environmental Health, 1997, 69:115–124.

Increased risk of allergy in children due to formaldehyde exposure. Garrett MH et al. Allergy, 1999, 54:330–337.

Domestic exposure of to formaldehyde significantly increases the risk of asthma in young children. Rumchev K et al. European Respiratory Journal, 2002, 20:403–406.

Exposure to gaseous formaldehyde induces IgEmediated sensitization for formaldehyde in school-children. Wantke F et al. Clinical and Experimental Allergy, 1996, 26:276–280.

Indoor exposure to formaldehyde and risk of allergy. Kränke B, Aberer W.Allergy, 2000, 55:402–404.

Ambient formaldehyde levels and allergic disorders among Japanese pregnant women: baseline data from the Osaka maternal and child health study. Matsunaga I et al. Annals of Epidemiology, 2008, 18:78–84.

Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries: the National Cancer Institute cohort. Freeman LEB et al. Journal of the National Cancer Institute, 2009, 101:751–761.

Scientific Committee on Cosmetic Products and Non-food Products. Opinion concerning a clarification on the formaldehyde and para-formaldehyde entry in Directive 76/768/EEC on cosmetic products. Opinion: European Commission. 2002.

Other uses of formaldehyde have different restrictions in Canada. For example, nail hardeners may contain concentrations equal to or less than 5% and oral care products may contain concentrations equal to or less than 0.1%. Formaldehyde is not permitted in aerosol cosmetics. See Canada’s Cosmetic Ingredient Hotlist, March 2007.

Meta-analysis of formaldehyde and hematologic cancers in humans. Zhang et al 2009. Mutation Research 681: 150-168.

U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. ”Formaldehyde (Gas) CAS No. 50-00-0: Reasonably anticipated to be a human carcinogen.” Eleventh Report on Carcinogens. December 2002.

Avoiding Formaldehyde Allergic Reactions In Children. Jacob SE and Steele T. Pediatric Annals 2007;36(1):55-6.

Threshold for occluded formaldehyde patch test in formaldehyde-sensitive patients. Relationship to repeated open application test with a product containing formaldehyde releaser. Flyvholm MA, Hall BM, Agner T, Tiedemann E, Greenhill P, Vanderveken W, Freeberg FE, Menné T. Contact Dermatitis. 1997;36(1):26-33.

Environmental Exposures – A pediatric perspective on allergic contact dermatitis. Jacob SE, Breithaupt A. Skin & Aging. July 2009: 28-36.

Formaldehyde-releasing preservative in baby and cosmetic products. Moennich JN, Hanna DM, Jacob SE (2009). Journal of the Dermatology Nurses’ Association 1:211-214.

 

BENCENO

Advances in understanding benzene health effects and susceptibility. Smith, Martyn T. (2010). Ann Rev Pub Health 31: 133–48.

Leukemia risk associated with low-level benzene exposure. Glass DC, Gray CN, Jolley DJ, et al. Epidemiology. 2003;14:569–77.

Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy. Xing C, F Marchetti, G Li, RH Weldon, E Kurtovich, S Young, TE Schmid, L Zhang, S Rappaport, S Waidyanatha, AJ Wyrobek and B Eskenazi. 2010. Environmental Health Perspectives doi: 10.1289/ehp.0901531.

Benzene-induced cancers: abridged history and occupational health impact. Huff J (2007). Int J Occup Environ Health 13 (2): 213–21

The past suppression of industry knowledge of the toxicity of benzene to humans and potential bias in future benzene research. Infante PF. Int J Occup Environ Health. 2006;12:268–72.

ToxFAQs™ - Benceno (Benzene). ATSDR.

Projections of leukemia risk associated with occupational exposure to benzene. Infante PF, White MC. Am J Ind Med. 1985;7(5-6):403–13

Benzene exposure and multiple myeloma: a detailed meta-analysis of benzene cohort studies. Infante PF. Ann NY Acad Sci. 2006;1076:90–109.

Benzene exposure and risk of non-Hodgkin lymphoma. Smith MT, Jones RM, Smith AH. Cancer Epidemiol Biomarkers Prev. 2007;16:385–91

Benzene and lymphohematopoietic malignancies in humans. Hayes RB, Songnian Y, Dosemeci M, Linet M. Am J Ind. Med. 2001;40:117–26.

Benzene: a multipotential carcinogen. Results of long-term bioassays performed at the Bologna Institute of Oncology. Maltoni C, Conti B, Cotti G. Am J Ind Med. 1983;589:630.

Industry influence on occupational and environmental public health. Huff J. Int J Occup Environ Health. 2007;13:107–17.

The health watch case–control study of leukemia and benzene: the story so far. Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR. Ann NY Acad Sci. 2006 Sep;1076:80–9.

Health watch exposure estimates: do they underestimate benzene exposure? Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR Chem Biol Interact. 2005;153-154:23–32.

Maternal exposure to ambient levels of benzene and neural tube defect among offspring, Texas, 1999-2004. Lupo, PJ, E Symanski, DK Waller, MA Canfield and LE Mitchellet. 2010. Environmental Health Perspectives 119(3)

Benzene. TEACH Chemical Summary. U.S. EPA, Toxicity and Exposure Assessments for Children’s Health

Personal, indoor, and outdoor VOC exposures in a probability sample of children. Adgate, J.L., et al. 2004. J.Expo.Anal.Environ.Epidemiol. 14 Suppl 1:S4-S13.:S4-S13.  

Risk assessment of exposure to volatile organic compounds in different indoor environments. Guo, H., et al. 2004. Environ.Res. 94(1):57-66. 

Major sources of benzene exposure. Wallace LA. Environ Health Perspect. 1989 Jul;82:165-9.

Embryotoxic effects of benzene and its methyl derivatives: toluene, xylene. Hudak, A., and G. Ungvary. 1978. Toxicology 11(1):55-63.  

Association of domestic exposure to volatile organic compounds with asthma in young children. Rumchev, K., et al. 2004. Thorax 59(9):746-751.  

WHO guidelines for indoor air quality: selected pollutants. WHO Regional Office for Europe . 2010.

BENZENE: Air Quality and Exposure Assessment. JOINT RESEARCH CENTRE (JRC). European Commission.

 

TOLUENO

Fichas Internacionales de Seguridad Química TOLUENO ICSC: 0078. Octubre 2002

ToxFAQs™ - Tolueno (Toluene) Agencia para las Sustancias Tóxicas y Registro de Enfermedades (ATSDR)

CHE Toxicant and Disease Database. Toluene.

 

ESTIRENO

Fichas Internacionales de Seguridad Química. Estireno. ICSC: 0073.

ToxFAQs™ - Estireno (Styrene). Agencia para Sustancias Tóxicas y Registro de Enfermedades (ATSDR).

Collaborative on Heath and the Environment. Toxicant  and Disease Database. Styrene.

 

XILENO

ATSDR en Español - ToxFAQs™: Xileno

CHE. Toxicant and Disease Database. Xylene

 

DISOLVENTES

PROYECTO Fittema – Antena de transferencia de tecnología – Disolventes

Disolventes. Fodesam

Hidrocarburos alifáticos. INSHT

Disolventes. ToxTown en español

 

ÉTERES DE GLICOL BASADOS EN ETILENO

CHE Toxicant and Disease Database. Ethylene glycol ethers.

Bbdd risctox > ficha de sustancia. 2-butoxietanol. Istas.

Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS NO. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program

Glycol Ethers. Hazard Evaluation System and Information Service. Fact Sheet.

2-Butoxietanol y acetato de 2-butoxietanol (2-Butoxyethanol and 2-Butoxyethanol Acetate). ATSDR

 

TRICLOROETILENO

WHO guidelines for indoor air quality: selected pollutants. WHO Regional Office for Europe . 2010.

Toxicant and Disease Database » trichloroethylene (TCE).

European Union risk assessment report. Trichloroethylene. Brussels, European Commission, 2004.

Outdoor, indoor, and personal exposure to VOCs in children. Adgate JL et al. Environmental Health Perspectives, 2004, 112:1386–1392.

Comparison of personal, indoor, and outdoor exposures to hazardous air pollutants in three urban communities. Sexton K, Adgate JL, Ramachandran G, Pratt GC, Mongin SJ, Stock TH, et al. Environ Sci Technol. 2004b;38:423–430

 

TETRACLOROETILENO

Toxicant and Disease Database » tetrachloroethylene (PCE)

Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for tetrachloroethylene. Atlanta, GA, US Department of Health and Human Services, 1997.

Tetrachloroethylene. Priority substances assessment report for the Canadian Environmental Protection Act. Ottawa, Environment Canada and Health Canada, 1993

WHO guidelines for indoor air quality: selected pollutants. WHO Regional Office for Europe. 2010.

Indoor exposure to perchloroethylene (PCE) in individuals living with dry-cleaning workers. Aggazzotti G et al. Science of the Total Environment, 1994, 156:133–137

Tetrachloroethylene (PCE, perc) levels in residential dry cleaner buildings in diverse communities in New York City. McDermott MJ et al. Environmental Health Perspectives, 2005, 113:1336–1343.

Tetrachloroethylene emissions and exposure in dry cleaning. Raisanen J, Niemela R, Rosenberg C. Journal of the Air & Waste Management  Association, 2001, 51:1671–1675.

Factors influencing tetra-chloroethylene concentrations in residences above dry-cleaning establishments. Garetano G, Gochfeld M. Arch Environ Health. 2000;55:59–68.

Measurement of perchloroethylene indoor air levels caused by fugitive emissions from unvented dry-to-dry dry-cleaning units. Moschandreas DJ, Odea DS. Journal of the Air & Waste Management Association, 1995, 45:111–115.

Neurobehavioral and neurophysiological outcome of chronic low-level tetrachloroethene exposures measured in neighborhoods of dry cleaning shops. Altmann L, Neuhann HF, Kramer U, Witten J, Jermann E. Environ Res. 1995;69:83–89.

PARABENOS

Toxic effects of the easily avoidable phthalates and parabens. Crinnion WJ. Altern Med Rev. 2010 Sep;15(3):190-6.

Effects of propyl paraben on the male reproductive system. Oishi S. Food Chem Toxicol. 2002 Dec;40(12):1807-13.

Effects of butylparaben on the male reproductive system in rats. Oishi S. Toxicol Ind Health. 2001 Feb;17(1):31-9.

Parabens in male infertility-is there a mitochondrial connection? Tavares RS, Martins FC, Oliveira PJ, Ramalho-Santos J, Peixoto FP. Reprod Toxicol. 2009 Jan;27(1):1-7. doi: 10.1016/j.reprotox.2008.10.002. Epub 2008 Oct 21.

Opinion on Parabens. Scientific Committee on Consumer Safety .  SCCS/1348/10. Revision 22 March 2011 COLIPA n° P82 http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_041.pdf

Concentrations of Parabens in Human Breast Tumours .Journal of Applied Toxicology v. 24, i. 1, 1jan 04. P.D. Dardre, A. Aljarrah, W.R. Miller, N.G. Coldham . M.J. Sauer and G.S. Pope.

Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. Darbre PD and Harvey PW. J Appl Toxicol.28, 5 (Jul 2008):561-78.

http://www.theorganicpharmacy.com/Images/Content/ExpertAdvice/FactSheets/Files/107.pdf

Environmental Working Group. Skin Deep. Parabens. Available online: http://www.cosmeticsdatabase.com/ingredient.php?ingred06=704450&refurl=%2Fproduct.php%3Fprod_id%3D17311%26.

Environmental Working Group. Skin Deep. Methylparaben. Available online: Environmental Working Group. Skin Deep. Parabens. Available online: http://www.cosmeticsdatabase.com/ingredient.php?ingred06=704450&refurl=%2Fproduct.php%3Fprod_id%3D17311%26.

Environmental Working Group. Skin Deep. Butylparaben. Available online: http://www.cosmeticsdatabase.com/ingredient.php?ingred06=700868.

Environmental Working Group. Skin Deep. Propylparaben. Available online: http://www.cosmeticsdatabase.com/ingredient.php?ingred06=705335.

Effects of methyl paraben on skin keratinocytes. Ishiwatari S, Suzuki T, Hitomi T, Yoshino T, Matsukuma S, Tsuji T. (2006). Journal of Applied Toxicology 27:1-9.

Methylparaben potentiates UV-induced damage on skin keratinocytes. Handa O, Kokura S, Adachi S, Takagi T, Naito Y, Tanigawa T, Yoshida N, Yoshikawa T. (2006). Toxicology. 227: 62-72.

Cosmetic chemicals found in breast tumours. Newscientist.  12 January 2004

Endocrine disrupters and human health: Could estrogenic chemicals in body care cosmetics adversely affect breast cancer incidence in women? A review of evidence and call for further research.Harvey, Ph W.; Darbre, Ph Journal of Applied Toxicology (2004), 24(3), 167-176.

Contents of methylparaben, ethylparaben, propylparaben, butylparaben and benzylparaben in cosmetic products. Rastogi SC, Schouten A, Dekruijf N, Weijland JW (1995). Contact Dermatits 32: 28-30.

Ye X, Bishop AM, Reidy JA, Needham LL, Calafat AM (2006). Parabens as urinary biomarkers of exposure in humans. Environmental Health Perspectives114: 1843-1846.

Oestrogenic activity of parabens in MCF7 human breast cancer cells. Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD. J Steroid Biochem Mol Biol. 2002 Jan;80(1):49-60.

Some Alkyl Hydroxy Benzoate Preservatives (Parabens) Are Estrogenic. Edwin J. Routledge, et al Toxicology and Applied Pharmacology. 153(1), 12-19.

Paraben allergy. Nagel JE, Fuscaldo JT, Fireman P. JAMA. 1977, Apr 11; 237(15):1594-5.

Un individuo medio podría estar expuesto a unos 76 mg/día de parabenos, según Blanca Diaz Ley, y otros autores, del Servicio de Dermatología del Inst. de Salud Carlos III de Madrid, que publicaron una revisión sobre el tema. Piel. 2006;21(5):231-40. Aunque estos autores en concreto,  concluían que no había nada definitivo sobre la maldad de estos productos, a pesar de la abundante literatura científica en sentido contrario